About: aroA and aroD mutations influence biofilm formation in Salmonella Enteritidis

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	aro mutants of Salmonella enterica are frequently used as live vaccines for oral vaccination of domestic animals. Interestingly, besides their auxotrophy, they appear to be of reduced resistance to the components of the innate immune response due to a defect in outer membrane and/or cell wall integrity. We were interested in the ability of aroA and aroD mutants of S. Enteritidis to adhere to solid surfaces. aroA and aroD mutants did not adhere to solid surfaces although they bind Congo red and produced D-mannose and D-glucose capsular polysaccharides in the same amount as the wild type strain. However the aro mutants exhibited a decreased production of cellulose, N-acetyl-D-glucosamine or N-acetylneuraminic acid containing capsular polysaccharide and fimbriae which explains their inability to form biofilms. aroA and aroD containing plasmids complemented all the defects of the aro mutants. Beside its attenuation for host, the loss of ability to form biofilm is additional characteristic of aro mutants. aro mutants of Salmonella enterica are frequently used as live vaccines for oral vaccination of domestic animals. Interestingly, besides their auxotrophy, they appear to be of reduced resistance to the components of the innate immune response due to a defect in outer membrane and/or cell wall integrity. We were interested in the ability of aroA and aroD mutants of S. Enteritidis to adhere to solid surfaces. aroA and aroD mutants did not adhere to solid surfaces although they bind Congo red and produced D-mannose and D-glucose capsular polysaccharides in the same amount as the wild type strain. However the aro mutants exhibited a decreased production of cellulose, N-acetyl-D-glucosamine or N-acetylneuraminic acid containing capsular polysaccharide and fimbriae which explains their inability to form biofilms. aroA and aroD containing plasmids complemented all the defects of the aro mutants. Beside its attenuation for host, the loss of ability to form biofilm is additional characteristic of aro mutants. (en)
Title	aroA and aroD mutations influence biofilm formation in Salmonella Enteritidis aroA and aroD mutations influence biofilm formation in Salmonella Enteritidis (en)
skos:prefLabel	aroA and aroD mutations influence biofilm formation in Salmonella Enteritidis aroA and aroD mutations influence biofilm formation in Salmonella Enteritidis (en)
skos:notation	RIV/00027162:_____/09:#0000502!RIV10-MZE-00027162
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LC06030), Z(MZE0002716201)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Malcová, Marcela Rychlík, Ivan Karasová, Daniela
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	304061
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/09:#0000502
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Salmonella; biofilm; aroA; aroD; cellulose (en)
http://linked.open.../riv/klicoveSlovo	Salmonella cellulose aroA aroD biofilm
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[9EBE1A24CB15]
http://linked.open...i/riv/nazevZdroje	FEMS Microbiology Letters
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Biomolecular centre
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	291
http://linked.open...iv/tvurceVysledku	Karasová, Daniela Malcová, Marcela Rychlík, Ivan
http://linked.open...ain/vavai/riv/wos	000262224700005
http://linked.open...n/vavai/riv/zamer	Zdravá zvířata a bezpečné potraviny jako základ pro zdraví lidí
issn	0378-1097
number of pages	6 (xsd:int)
is http://linked.open...avai/riv/vysledek of	aroA and aroD mutations influence biofilm formation in Salmonella Enteritidis aroA and aroD mutations influence biofilm formation in Salmonella Enteritidis aroA and aroD mutations influence biofilm formation in Salmonella Enteritidis aroA and aroD mutations influence biofilm formation in Salmonella Enteritidis

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