About: Synthesis and biocompatibility evaluation of fluorinated, single-tailed glucopyranoside surfactants     Goto   Sponge   NotDistinct   Permalink

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Description
  • Částečně fluorované neionogenní surfaktanty jsou zajímavé pro celou řadu biomedicínských aplikací, jako podávání léčiv pulmonárně s využitím reverzních mikroemulzí. Byla popsána syntéza a charakterizace série částečně fluorovaných ß-D-glucopyranosidových surfaktantů. Na základě úvodních testů biokompatibility se prokázalo, že fluorované surfaktanty jsou méně toxické in vitro na tkáňových kulturách a mají nižší hemolytickou aktivitu ve srovnání s uhlovodíkovými analogy. Celkově tyto výsledky naznačují, že styto surfaktanty mohou být využitelné pro pro biomedicínské aplikace, jako například nové nosiče léčiv. (cs)
  • Partially fluorinated non-ionic surfactants are of interest for a range of biomedical applications, such as the pulmonary administration of drugs using reverse water-in-perfluorocarbon microemulsions. The synthesis and characterization of a series of partially fluorinated ß-D-glucopyranoside surfactants. Based on an initial biocompatibility assessment the fluorinated surfactants appear to be less toxic towards cells in culture and to have a lower haemolytic activity compared to their hydrocarbon analogues. Overall, these findings suggest that the surfactants may be useful for biomedical applications, such as novel drug delivery systems.
  • Partially fluorinated non-ionic surfactants are of interest for a range of biomedical applications, such as the pulmonary administration of drugs using reverse water-in-perfluorocarbon microemulsions. The synthesis and characterization of a series of partially fluorinated ß-D-glucopyranoside surfactants. Based on an initial biocompatibility assessment the fluorinated surfactants appear to be less toxic towards cells in culture and to have a lower haemolytic activity compared to their hydrocarbon analogues. Overall, these findings suggest that the surfactants may be useful for biomedical applications, such as novel drug delivery systems. (en)
Title
  • Synthesis and biocompatibility evaluation of fluorinated, single-tailed glucopyranoside surfactants
  • Synthesis and biocompatibility evaluation of fluorinated, single-tailed glucopyranoside surfactants (en)
  • Hodnocení syntézy a biokompatibility fluorovaných, jednochvostových glukopyranosidových surfaktantů (cs)
skos:prefLabel
  • Synthesis and biocompatibility evaluation of fluorinated, single-tailed glucopyranoside surfactants
  • Synthesis and biocompatibility evaluation of fluorinated, single-tailed glucopyranoside surfactants (en)
  • Hodnocení syntézy a biokompatibility fluorovaných, jednochvostových glukopyranosidových surfaktantů (cs)
skos:notation
  • RIV/00027162:_____/08:#0000457!RIV09-MZE-00027162
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(QF3115), Z(MZE0002716201)
http://linked.open...iv/cisloPeriodika
  • 12
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 398714
http://linked.open...ai/riv/idVysledku
  • RIV/00027162:_____/08:#0000457
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • BETA-D-GLUCOPYRANOSIDES; AIR-WATER-INTERFACE; CHAIN ALKYL GLYCOPYRANOSIDES; IN-FLUOROCARBON EMULSIONS; KOENIGS-KNORR REACTION; BIOMEDICAL APPLICATIONS; CARBOXYLIC-ACIDS; PERFLUOROALKYLATED AMPHIPHILES; LYOTROPIC PROPERTIES; PHASE-BEHAVIOR (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [3AC683FD0A68]
http://linked.open...i/riv/nazevZdroje
  • New Journal of Chemistry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 32
http://linked.open...iv/tvurceVysledku
  • Li, X.
  • Mašek, Josef
  • Turánek, Jaroslav
  • Kudláčková, Hana
  • Knötigová, Pavlína
  • Knutson, B.
  • Lehmler, H.
  • Pennington, D.
  • Rankin, S.
http://linked.open...ain/vavai/riv/wos
  • 000261747700015
http://linked.open...n/vavai/riv/zamer
issn
  • 1144-0546
number of pages
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