About: Effects of postnatal exposure to benzo[a]pyrene on the immunity of immature rats

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cílem studie bylo charakterizovat vliv benzo(a)pyrenu (B(a)P) na vyvíjející se imunitní systém novorozených potkanů. Zvířata byla vystavena rozdílné koncentraci (0,1; 1,0 a 10,0 mg/kg/den) B(a)P v průběhu prvních 14 dní života a utracena 23.den experimentu Laboratorními analýzami bylo zjištěno, že klesající počet erytrocytů byl v přímé korelaci s dávkou B(a)P. U exponovaných zvířat také stoupal počet T lymfocytů a jejich mitogenní aktivita. Naopak produkce cytokinů IFN-gama a IL-4 měřená na úrovni mRNA byla nižší než u neexponovaných zvířat. Pokles poměru IFN-gama/IL-4 byl závislý na dávce B(a)P. Z těchto údajů se dá usoudit na to, že expozice novorozených mláďat účinku B(a)P může modulovat imunitní odpověď na infekci a/nebo vakcinaci. (cs) To determine the effect of benzo[a]pyrene (B[a]P) on the developing immune system of immature rats, newborn animals received different concentrations (0.1, 1.0 and 10.0 mg/kg/day) of B[a]P in the first 14 days after birth. These rats were euthanised on day 23 of the experiment and it was found that the decreasing numbers of erythrocytes were in direct correlation to the dose of B[a]P. In subject animals, the overall counts of T cells in the spleen and the mitogenic activity increased. A decrease in the production of both IFN-gama and IL-4 (measured at the mRNA level) as well as the decreasing IFN-gama/IL-4 ratio in rat splenocytes were dependent on the dose of B[a]P. From this we may deduce that exposure to B[a]P in immature animals may modulate the immune response to infection and/or vaccination. To determine the effect of benzo[a]pyrene (B[a]P) on the developing immune system of immature rats, newborn animals received different concentrations (0.1, 1.0 and 10.0 mg/kg/day) of B[a]P in the first 14 days after birth. These rats were euthanised on day 23 of the experiment and it was found that the decreasing numbers of erythrocytes were in direct correlation to the dose of B[a]P. In subject animals, the overall counts of T cells in the spleen and the mitogenic activity increased. A decrease in the production of both IFN-gama and IL-4 (measured at the mRNA level) as well as the decreasing IFN-gama/IL-4 ratio in rat splenocytes were dependent on the dose of B[a]P. From this we may deduce that exposure to B[a]P in immature animals may modulate the immune response to infection and/or vaccination. (en)
Title	Effects of postnatal exposure to benzo[a]pyrene on the immunity of immature rats Vliv postnatální expozice účinku benzo[a]pyrenu na imunitu novorozených potkanů (cs) Effects of postnatal exposure to benzo[a]pyrene on the immunity of immature rats (en)
skos:prefLabel	Effects of postnatal exposure to benzo[a]pyrene on the immunity of immature rats Vliv postnatální expozice účinku benzo[a]pyrenu na imunitu novorozených potkanů (cs) Effects of postnatal exposure to benzo[a]pyrene on the immunity of immature rats (en)
skos:notation	RIV/00027162:_____/08:#0000333!RIV09-MZE-00027162
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA525/05/2695), Z(MZE0002716201)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Faldyna, Martin Matiašovic, Ján Mašková, Jarmila Levá, Lenka Kummer, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	365417
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/08:#0000333
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	polycyclic aromatic hydrocarbons; immunity; IFN-gama; IL-4; cytokines (en)
http://linked.open.../riv/klicoveSlovo	cytokines immunity polycyclic aromatic hydrocarbons IFN-gama IL-4
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[1714D2C21FC2]
http://linked.open...i/riv/nazevZdroje	Veterinární medicína
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Effects of neonatal exposure to polycyclic aromatic hydrocarbons on the reproductive and immune systém
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	53
http://linked.open...iv/tvurceVysledku	Faldyna, Martin Levá, Lenka Matiašovic, Ján Kummer, Vladimír Mašková, Jarmila
http://linked.open...ain/vavai/riv/wos	000253944700005
http://linked.open...n/vavai/riv/zamer	Zdravá zvířata a bezpečné potraviny jako základ pro zdraví lidí
issn	0375-8427
number of pages	8 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Effects of postnatal exposure to benzo[a]pyrene on the immunity of immature rats Effects of postnatal exposure to benzo[a]pyrene on the immunity of immature rats Effects of postnatal exposure to benzo[a]pyrene on the immunity of immature rats Effects of postnatal exposure to benzo[a]pyrene on the immunity of immature rats

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