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Description
  • Stable lyophilised liposomal preparation of encapsulated paclitaxel (7 mol %) was prepared by various procedures: hydration of lipid film, the proliposome-liposome method and lyophilisation from 2-methylbutan-2-ol. Process of extrusion was applied to reduce size distribution of liposomes to 180-190 nm. Negative charge (zeta-potential of -30 mV in PBS buffer) was sufficient to prevent fusion of liposomes. Size distribution and zeta-potential of liposomes were determined by dynamic light scattering. Saccharides were tested as cryoprotectants. Sucrose, trehalose and lactose were equally cryoprotective at lipid: sugar molar ratios of 1:5 and 1:10.
  • Stable lyophilised liposomal preparation of encapsulated paclitaxel (7 mol %) was prepared by various procedures: hydration of lipid film, the proliposome-liposome method and lyophilisation from 2-methylbutan-2-ol. Process of extrusion was applied to reduce size distribution of liposomes to 180-190 nm. Negative charge (zeta-potential of -30 mV in PBS buffer) was sufficient to prevent fusion of liposomes. Size distribution and zeta-potential of liposomes were determined by dynamic light scattering. Saccharides were tested as cryoprotectants. Sucrose, trehalose and lactose were equally cryoprotective at lipid: sugar molar ratios of 1:5 and 1:10. (en)
  • Stabilní lyofilizovaný liposomální preparát obsahující 7 mol % paclitaxelu byl připraven různými metodami: hydratací lipidového filmu, metodou proliposom-liposom a lyofilizací z 2-methylbutan-2-olu. Technika extruze byla použita pro snížení velikosti liposomů na 180 - 190 nm. Negativní náboj (hodnota zeta-potenciálu -30 mV v PBS pufru) chránil liposomy před jejich vzájemnou fúzí. Distribuce velikosti a zeta-potenciál liposomů byly stanoveny metodou dynamického rozptylu světla. Sacharidy byly testovány jako kryoprotektiva. Sacharosa, trehalosa a laktosa při molárním poměru lipid:sacharid 1:5 a 1:10 měly stejný kryoprotektivní účinek. (cs)
Title
  • Liposomes with high encapsulation capacity for paclitaxel: preparation and characterisation
  • Liposomy s vysokou enkapsulační kapacitou pro paclitaxel: příprava a charakteristika (cs)
  • Liposomes with high encapsulation capacity for paclitaxel: preparation and characterisation (en)
skos:prefLabel
  • Liposomes with high encapsulation capacity for paclitaxel: preparation and characterisation
  • Liposomy s vysokou enkapsulační kapacitou pro paclitaxel: příprava a charakteristika (cs)
  • Liposomes with high encapsulation capacity for paclitaxel: preparation and characterisation (en)
skos:notation
  • RIV/00027162:_____/07:#0000239!RIV08-MZE-00027162
http://linked.open.../vavai/riv/strany
  • 176;183
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MZE0002716201)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 431176
http://linked.open...ai/riv/idVysledku
  • RIV/00027162:_____/07:#0000239
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Liposomes; paclitaxel; lyophilization; stability (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [F29C918C737E]
http://linked.open...v/mistoKonaniAkce
  • Pardubice
http://linked.open...i/riv/mistoVydani
  • Pardubice
http://linked.open...i/riv/nazevZdroje
  • 14th Young Investigators' Seminar on Analytical Chemistry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Koudelka, Štěpán
  • Turánek, Jaroslav
http://linked.open...vavai/riv/typAkce
http://linked.open.../riv/zahajeniAkce
http://linked.open...n/vavai/riv/zamer
number of pages
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  • Univerzita Pardubice
https://schema.org/isbn
  • 978-80-7194-969-5
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