About: Genetic variability of bovine respiratory syncytial virus     Goto   Sponge   NotDistinct   Permalink

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  • The study of genetic vaiability is of BRSV is based mainly on sequence analysis of glycoprotein G gene, which is the most variable viral protein. In our study, multiple sequence alignment at nucleotide and amino acid levels of 15 different BRSV isolateswas carried out. The nucleotide and amino acid sequence of proteinectodomain revealed 87.3-97.4 % and 77.2-95.7 % homology, respectively. The sequence variability has been distributed equally along the whole gene of ectodomain, howeve, the nonsynonymoussubstitutions were located predominantly in two mucin-like regions of the protein. It is conceivable that the mutations of these regions are subject to the selective immune pressure.
  • The study of genetic vaiability is of BRSV is based mainly on sequence analysis of glycoprotein G gene, which is the most variable viral protein. In our study, multiple sequence alignment at nucleotide and amino acid levels of 15 different BRSV isolateswas carried out. The nucleotide and amino acid sequence of proteinectodomain revealed 87.3-97.4 % and 77.2-95.7 % homology, respectively. The sequence variability has been distributed equally along the whole gene of ectodomain, howeve, the nonsynonymoussubstitutions were located predominantly in two mucin-like regions of the protein. It is conceivable that the mutations of these regions are subject to the selective immune pressure. (en)
  • Studium genetické variability bovinního respiračního syncytiálního viru je založeno především na srovnání sekvencí genu pro glykoprotein G, který je nejvíce variabilním virovým proteinem. V naší studui byly srovnány nukleotidové a aminokyselinové sekvence 15 různých izolátů BRSV. Nukleotidové sekvence kódující ektodoménu glykoproteinu G vykazovaly shodu v rozsahu 87,3-97,4 %, aminokyselinové pak v rozsahu 77,2-95,7 %. I když variabilita sekvencí byla rozmístěna rovnoměrně podél celé délky genu, nesynonymní mutace byly četnější ve dvou %22mucin-like%22 regionech proteinu. Mutace v těchto regionech mohou být výrazem selekčního tlaku imunitního systému zvířat na virové proteiny. (cs)
Title
  • Genetic variability of bovine respiratory syncytial virus
  • Genetická variabilita bovinního respiračního syncytaálního viru (cs)
  • Genetic variability of bovine respiratory syncytial virus (en)
skos:prefLabel
  • Genetic variability of bovine respiratory syncytial virus
  • Genetická variabilita bovinního respiračního syncytaálního viru (cs)
  • Genetic variability of bovine respiratory syncytial virus (en)
skos:notation
  • RIV/00027162:_____/04:00011010!RIV/2005/MZE/M03005/N
http://linked.open.../vavai/riv/strany
  • 78;80
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MZE0002716201)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 565345
http://linked.open...ai/riv/idVysledku
  • RIV/00027162:_____/04:00011010
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • BRSV;G protein;genetic variability (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [7E9429E0E9F3]
http://linked.open...v/mistoKonaniAkce
  • Košice
http://linked.open...i/riv/mistoVydani
  • Košice
http://linked.open...i/riv/nazevZdroje
  • Infekčné a parazitárne choroby zvierat, 9.- 10.9.2004, Košice
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Kovařčík, Kamil
http://linked.open...vavai/riv/typAkce
http://linked.open.../riv/zahajeniAkce
http://linked.open...n/vavai/riv/zamer
number of pages
http://purl.org/ne...btex#hasPublisher
  • Univerzita veterinárskeho lekárstva v Košiciach
https://schema.org/isbn
  • 80-8077-007-7
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