About: Inhibition of GAP junctional intercellular comunication by noncoplanar polychlorinated biphenyls: inhibitory potencies and screening for potential mode(s) of action

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About: Inhibition of GAP junctional intercellular comunication by noncoplanar polychlorinated biphenyls: inhibitory potencies and screening for potential mode(s) of action Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Inhibition of gap junctional intercellular communication (GJIC) belongs among critical epigenetic events of tumor promotion. We determined relative potencies of a series of environmentally relevant PCB congeners to inhibit GJIC in vitro in a rat liver epithelial WB-F344 cells. The nonplanar PCBs were potent inhibitors of GJIC, whereas the dioxin-like PCBs did not inhibit GJIC. In contrast to phorbol ester and epidermal growth factor, prototypal tumor promoters, noncoplanar PCB 153 elicited a long-term downregulation of GJIC (up to 48 h). Various intracellular signaling pathways potentially involved in inhibition of GJIC were screened by using specific chemical probes inhibiting serine/threonine kinases, tyrosine kinases and phspholipases. Phosphocholine/specific phospholipase or sphingomyelinase and a tyrosine kinase might be upstream regulators of PCB/induced inhibition of GJIC. Inhibition of gap junctional intercellular communication (GJIC) belongs among critical epigenetic events of tumor promotion. We determined relative potencies of a series of environmentally relevant PCB congeners to inhibit GJIC in vitro in a rat liver epithelial WB-F344 cells. The nonplanar PCBs were potent inhibitors of GJIC, whereas the dioxin-like PCBs did not inhibit GJIC. In contrast to phorbol ester and epidermal growth factor, prototypal tumor promoters, noncoplanar PCB 153 elicited a long-term downregulation of GJIC (up to 48 h). Various intracellular signaling pathways potentially involved in inhibition of GJIC were screened by using specific chemical probes inhibiting serine/threonine kinases, tyrosine kinases and phspholipases. Phosphocholine/specific phospholipase or sphingomyelinase and a tyrosine kinase might be upstream regulators of PCB/induced inhibition of GJIC. (en)
Title	Inhibition of GAP junctional intercellular comunication by noncoplanar polychlorinated biphenyls: inhibitory potencies and screening for potential mode(s) of action Inhibition of GAP junctional intercellular comunication by noncoplanar polychlorinated biphenyls: inhibitory potencies and screening for potential mode(s) of action (en)
skos:prefLabel	Inhibition of GAP junctional intercellular comunication by noncoplanar polychlorinated biphenyls: inhibitory potencies and screening for potential mode(s) of action Inhibition of GAP junctional intercellular comunication by noncoplanar polychlorinated biphenyls: inhibitory potencies and screening for potential mode(s) of action (en)
skos:notation	RIV/00027162:_____/03:00008481!RIV/2004/GA0/M03004/N
http://linked.open.../vavai/riv/strany	102;111
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA525/00/D101)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Machala, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	610563
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/03:00008481
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	WB-F344 cell line;gap junctions;PCB congeners;MAP kinases;phospholipases (en)
http://linked.open.../riv/klicoveSlovo	gap junctions PCB congeners MAP kinases phospholipases WB-F344 cell line
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[449A38BDD8A6]
http://linked.open...i/riv/nazevZdroje	Toxicological Sciences
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	In vitro methods for detection and studies of epigenetic toxicity of xenobiotics
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	76
http://linked.open...iv/tvurceVysledku	Machala, Miroslav
issn	1096-6080
number of pages	10 (xsd:int)

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