About: Induced pluripotent stem (iPS) cells in domestic animals recent achievements

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About: Induced pluripotent stem (iPS) cells in domestic animals recent achievements - a review Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.vuzv.cz/sites/File/_privat/13083.pdf
Description	Pluripotent cells show the unlimited self-renewal capacity and the potential to differentiate into the cell lineages originating from three germ layers. To date real pluripotent stem cell lines, able to generate germ line chimeras, have been established in rodents. Large domestic animals, especially pig, due to their considerable anatomical and physiological similarities with humans are thought to be convenient model to test potential of pluripotent cells in cell replacement therapy before their clinical use. However, creating pluripotent cells in domestic animals until now has met the limitations due to lack of evidence for germ line contribution. Therefore they can not be considered real pluripotent cells but rather putative embryonic or embryonic-like stem cells. Recently, much attention has been drawn to the reprogramming technologies which enable redirection of differentiated somatic cells to the pluripotent status. The aim of this review is to present the recent achievements in generating of induced pluripotent stem (iPS) cells in domestic animals. Pluripotent cells show the unlimited self-renewal capacity and the potential to differentiate into the cell lineages originating from three germ layers. To date real pluripotent stem cell lines, able to generate germ line chimeras, have been established in rodents. Large domestic animals, especially pig, due to their considerable anatomical and physiological similarities with humans are thought to be convenient model to test potential of pluripotent cells in cell replacement therapy before their clinical use. However, creating pluripotent cells in domestic animals until now has met the limitations due to lack of evidence for germ line contribution. Therefore they can not be considered real pluripotent cells but rather putative embryonic or embryonic-like stem cells. Recently, much attention has been drawn to the reprogramming technologies which enable redirection of differentiated somatic cells to the pluripotent status. The aim of this review is to present the recent achievements in generating of induced pluripotent stem (iPS) cells in domestic animals. (en)
Title	Induced pluripotent stem (iPS) cells in domestic animals recent achievements - a review Induced pluripotent stem (iPS) cells in domestic animals recent achievements - a review (en)
skos:prefLabel	Induced pluripotent stem (iPS) cells in domestic animals recent achievements - a review Induced pluripotent stem (iPS) cells in domestic animals recent achievements - a review (en)
skos:notation	RIV/00027014:_____/13:#0001852!RIV14-MZE-00027014
http://linked.open...avai/predkladatel	Výzkumný ústav živočišné výroby, v.v.i.
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MZE0002701401)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Chronowska, Ewa
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav živočišné výroby, v.v.i.
http://linked.open...dnocenehoVysledku	79581
http://linked.open...ai/riv/idVysledku	RIV/00027014:_____/13:#0001852
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	differentiation, iPS cells, pluripotency, proliferation, regenerative medicine, reprograming (en)
http://linked.open.../riv/klicoveSlovo	iPS cells regenerative medicine reprograming pluripotency differentiation proliferation
http://linked.open...odStatuVydavatele	PL - Polská republika
http://linked.open...ontrolniKodProRIV	[11353C5BF25D]
http://linked.open...i/riv/nazevZdroje	Animal Science Papers and Reports
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	1 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	31
http://linked.open...iv/tvurceVysledku	Chronowska, Ewa
http://linked.open...ain/vavai/riv/wos	000320487100001
http://linked.open...n/vavai/riv/zamer	Od rostoucího oocytu k produkci embryí in vitro a embryonálním kmenovým buňkám: Vývojové modely a strategie produkce zárodečných, embryonálních a somatických buněk in vitro v kontextu s jejich využitím v programu zachování genetických živočišných zdrojů
issn	0860-4037
number of pages	11 (xsd:int)

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