About: In vitro ageing of pig oocytes: effects of the histone deacetylase inhibitor trichostatin A     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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Description
  • Po maturaci (zrání) in vitro neoplozené prasečí oocyty procházejí procesem zvaným stárnutí. Tento proces zahrnuje typické jevy, jako je fragmentace, spontánní partenogenetická aktivace nebo lýza. Inhibice histon deacetylázy pomocí specifického inhibitoru trichostatinu A (TSA) signifikantně oddalovalo zrání prasečích oocytů kultivovaných in vitro. Stárnutí oocytů dozrávajících pod vlivem TSA probíhá stejně jako u oocytů dozrávajících bez TSA. Inhibice histon deacetylázy během stárnutí oocytu signifikantně snižovala podíl fragmentovaných oocytů. Partenogenetický vývoj oocytů stárnoucích za působení TSA je podobný jako vývoj čerstvých oocytů (29 % blastocyst) uměle aktivovaných bezprostředně po maturaci in vitro. (cs)
  • After in vitro maturation, the unfertilized pig oocytes underwent the process called ageing. This process involves typical events such as fragmentation, spontaneous parthenogenetic activation or lysis. Inhibition of histone deacetylase, using its specific inhibitor trichostatin A (TSA), significantly delayed the maturation of pig oocytes cultured in vitro. The ageing of oocytes matured under the effect of TSA is the same as the ageing in oocytes matured without TSA. The inhibition of histone deacetylase during oocyte ageing significantly reduced the percentage of fragmented oocytes. The parthenogenetic development in oocytes aged under TSA treatment is similar to the development of fresh oocytes (29% of blastocyst) artificially activated immediately after in vitro maturation.
  • After in vitro maturation, the unfertilized pig oocytes underwent the process called ageing. This process involves typical events such as fragmentation, spontaneous parthenogenetic activation or lysis. Inhibition of histone deacetylase, using its specific inhibitor trichostatin A (TSA), significantly delayed the maturation of pig oocytes cultured in vitro. The ageing of oocytes matured under the effect of TSA is the same as the ageing in oocytes matured without TSA. The inhibition of histone deacetylase during oocyte ageing significantly reduced the percentage of fragmented oocytes. The parthenogenetic development in oocytes aged under TSA treatment is similar to the development of fresh oocytes (29% of blastocyst) artificially activated immediately after in vitro maturation. (en)
Title
  • In vitro ageing of pig oocytes: effects of the histone deacetylase inhibitor trichostatin A
  • In vitro ageing of pig oocytes: effects of the histone deacetylase inhibitor trichostatin A (en)
  • Stárnutí prasečích oocytů in vitro: působení inhibitoru histon deacetylázy trichostatinu A (cs)
skos:prefLabel
  • In vitro ageing of pig oocytes: effects of the histone deacetylase inhibitor trichostatin A
  • In vitro ageing of pig oocytes: effects of the histone deacetylase inhibitor trichostatin A (en)
  • Stárnutí prasečích oocytů in vitro: působení inhibitoru histon deacetylázy trichostatinu A (cs)
skos:notation
  • RIV/00027014:_____/08:#0000907!RIV09-MZE-00027014
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(QG50052), Z(MZE0002701401), Z(MZE0002716201)
http://linked.open...iv/cisloPeriodika
  • May
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 371772
http://linked.open...ai/riv/idVysledku
  • RIV/00027014:_____/08:#0000907
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Ageing; histone deacetylase; oocyte; pig; trichostatin A (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [9A147F1F0CE9]
http://linked.open...i/riv/nazevZdroje
  • Zygote
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 16
http://linked.open...iv/tvurceVysledku
  • Petr, Jaroslav
  • Krejčová, T.
http://linked.open...ain/vavai/riv/wos
  • 000255266500006
http://linked.open...n/vavai/riv/zamer
issn
  • 0967-1994
number of pages
is http://linked.open...avai/riv/vysledek of
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