About: Effect of proteasome inhibitor MG132 on in vitro maturation of pig oocytes.     Goto   Sponge   NotDistinct   Permalink

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Description
  • Inhibitor proteasomu MG132 blokuje výstup meiotického zrání oocytů z metafáze I . Tento efekt byl patrný pouze v případě, že ovocyty byly vystaveny účinku inhibitoru před 18. hodinou kultivace in vitro. Efekty MG132 jsou plně reverzibilní, ale významná část ovocytů (45%) kultivovaných 48 hodin s MG132 a pak 24 hodin bez inhibitoru, nezastaví své zrání v metafázi II a dojde i nich ke spontánní partenogenetické aktivaci. (cs)
  • The proteasome inhibitor MG132 blocked the exit of maturing pig oocytes from metaphase I stage. The blocking effect was experienced only when oocytes were exposed to an inhibitor before 18th hour ofin vitro culture. The eefects of MG132 are fully reversible. However, a significant portion of oocytes (46%) cultured for 48 hours in MG132-supplemented medium and then for 24 hour in MG132-free medium did not block meiosis at the stage of metaphase II and underwent spontaneous parthenogenetic activation.
  • The proteasome inhibitor MG132 blocked the exit of maturing pig oocytes from metaphase I stage. The blocking effect was experienced only when oocytes were exposed to an inhibitor before 18th hour ofin vitro culture. The eefects of MG132 are fully reversible. However, a significant portion of oocytes (46%) cultured for 48 hours in MG132-supplemented medium and then for 24 hour in MG132-free medium did not block meiosis at the stage of metaphase II and underwent spontaneous parthenogenetic activation. (en)
Title
  • Effect of proteasome inhibitor MG132 on in vitro maturation of pig oocytes.
  • Effect of proteasome inhibitor MG132 on in vitro maturation of pig oocytes. (en)
  • Efekt inhibitoru proteasomu MG132 na in vitro zráni prasečich oocytů (cs)
skos:prefLabel
  • Effect of proteasome inhibitor MG132 on in vitro maturation of pig oocytes.
  • Effect of proteasome inhibitor MG132 on in vitro maturation of pig oocytes. (en)
  • Efekt inhibitoru proteasomu MG132 na in vitro zráni prasečich oocytů (cs)
skos:notation
  • RIV/00027014:_____/04:00010304!RIV/2005/MZE/M02005/N
http://linked.open.../vavai/riv/strany
  • 157-162
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(QD0085), Z(MZE0002701401)
http://linked.open...iv/cisloPeriodika
  • May
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 561987
http://linked.open...ai/riv/idVysledku
  • RIV/00027014:_____/04:00010304
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • oocyte;pig;maturation;proteasome;MG132 (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [968997C2DB0F]
http://linked.open...i/riv/nazevZdroje
  • Zygote
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 12
http://linked.open...iv/tvurceVysledku
  • Petr, Jaroslav
http://linked.open...n/vavai/riv/zamer
issn
  • 0967-1994
number of pages
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