About: Valganciclovir prophylaxis against cytomegalovirus impairs lymphocyte proliferation and activation in renal transplant r

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Antiviral prophylaxis against cytomegalovirus has been associated with reduced risk of allograft rejection and improved allograft survival after renal transplantation. This phenomenon might not be fully explained by preventing the indirect effects of cytomegalovirus. The effect of antiviral agents on lymphocyte function in patients treated with modern immunosuppression has not been studied to date. METHODS: Adult renal transplant recipients were assigned to 3-month prophylaxis with either valganciclovir (900 mg once daily; n=19) or valacyclovir (2 g four times daily; n=17) as part of an ongoing randomized trial. Subsets of lymphocytes, lymphocyte proliferation and/or cytokine production after in vitro mitogen stimulation were evaluated at the end of prophylaxis and 1 month after withdrawal of antiviral drugs. RESULTS: Lymphocyte proliferation was significantly decreased both after phytohemagglutinine (25% 15% versus 32% 18%; P=0.025) and concanavalin A stimulation (17% 9% versus 25% 16%; P=0.011) during valganciclovir, but not valacyclovir therapy. Moreover, a lower activated T-cell count (CD3(+)HLA-DR(+) cells) was noted in valganciclovir-treated patients (13% 10% versus 17% 12% of total CD3(+) T-cells; P=0.005). CONCLUSIONS: Valganciclovir suppresses lymphocyte proliferation and activation in patients after renal transplantation (en) Profylaxe valganciclovirem proti CMV snižuje proliferaci a aktivaci lymfocytů u pacientů po transplantaci ledviny. Profylaxe valganciclovirem proti CMV snižuje proliferaci a aktivaci lymfocytů u pacientů po transplantaci ledviny. (cs)
Title	Valganciclovir prophylaxis against cytomegalovirus impairs lymphocyte proliferation and activation in renal transplant r (en) Profylaxe valganciclovirem proti CMV snižuje proliferaci a aktivaci lymfocytů u pacientů po transplantaci ledviny Profylaxe valganciclovirem proti CMV snižuje proliferaci a aktivaci lymfocytů u pacientů po transplantaci ledviny (cs)
skos:prefLabel	Valganciclovir prophylaxis against cytomegalovirus impairs lymphocyte proliferation and activation in renal transplant r (en) Profylaxe valganciclovirem proti CMV snižuje proliferaci a aktivaci lymfocytů u pacientů po transplantaci ledviny Profylaxe valganciclovirem proti CMV snižuje proliferaci a aktivaci lymfocytů u pacientů po transplantaci ledviny (cs)
skos:notation	RIV/00023884:_____/11:#0004736!RIV12-MZ0-00023884
http://linked.open...avai/predkladatel	Nemocnice Na Homolce
http://linked.open...avai/riv/aktivita	N Z
http://linked.open...avai/riv/aktivity	N, Z(MSM0021620819)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Průcha, M. Sedláčková, Lenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Nemocnice Na Homolce
http://linked.open...dnocenehoVysledku	237826
http://linked.open...ai/riv/idVysledku	RIV/00023884:_____/11:#0004736
http://linked.open...riv/jazykVysledku	cze - čeština
http://linked.open.../riv/klicovaSlova	Lymphocyte proliferation, valganciclovir, valacyclovir, cytomegalovirus, renal t (en)
http://linked.open.../riv/klicoveSlovo	cytomegalovirus Lymphocyte proliferation renal t valacyclovir valganciclovir
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[0A3774C8C302]
http://linked.open...i/riv/nazevZdroje	Antiviral Therapy
http://linked.open...in/vavai/riv/obor	FE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	16
http://linked.open...iv/tvurceVysledku	Sedláčková, Lenka Průcha, Miroslav
http://linked.open...n/vavai/riv/zamer	Náhrada a podpora funkce některých životně důležitých orgánů
issn	1359-6535
number of pages	9 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Profylaxe valganciclovirem proti CMV snižuje proliferaci a aktivaci lymfocytů u pacientů po transplantaci ledviny Profylaxe valganciclovirem proti CMV snižuje proliferaci a aktivaci lymfocytů u pacientů po transplantaci ledviny

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