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  • Numerous studies have observed that offspring of bipolar parents manifest a broad spectrum of psychiatric disorders. We tested the hypothesis that in high risk offspring, bipolar disorder evolves in a predictable clinical sequence from non-specific (non-mood) to specific (mood) psychopathology. METHODS: Offspring from well-characterized families with one bipolar parent (high risk) or two well parents (controls) were assessed annually or at anytime symptoms developed using KSADS-PL interviews for up to 15 years. DSM-IV diagnoses were made on blind consensus review using all available clinical material. We compared the age-adjusted risks of lifetime psychopathology between high risk and control subjects and assessed the conditional probability of developing a mood disorder given a history of non-mood disorders. In subjects meeting full DSM-IV criteria for bipolar disorder, we assessed the sequence of psychopathology against a clinical staging model. RESULTS: High risk offspring manifest higher rates of
  • Numerous studies have observed that offspring of bipolar parents manifest a broad spectrum of psychiatric disorders. We tested the hypothesis that in high risk offspring, bipolar disorder evolves in a predictable clinical sequence from non-specific (non-mood) to specific (mood) psychopathology. METHODS: Offspring from well-characterized families with one bipolar parent (high risk) or two well parents (controls) were assessed annually or at anytime symptoms developed using KSADS-PL interviews for up to 15 years. DSM-IV diagnoses were made on blind consensus review using all available clinical material. We compared the age-adjusted risks of lifetime psychopathology between high risk and control subjects and assessed the conditional probability of developing a mood disorder given a history of non-mood disorders. In subjects meeting full DSM-IV criteria for bipolar disorder, we assessed the sequence of psychopathology against a clinical staging model. RESULTS: High risk offspring manifest higher rates of (en)
Title
  • Early stages in the development of bipolar disorder
  • Early stages in the development of bipolar disorder (en)
skos:prefLabel
  • Early stages in the development of bipolar disorder
  • Early stages in the development of bipolar disorder (en)
skos:notation
  • RIV/00023752:_____/10:00001045!RIV11-MZ0-00023752
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • V
http://linked.open...iv/cisloPeriodika
  • 1-2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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  • 255639
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  • RIV/00023752:_____/10:00001045
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  • bipolar disorders; staging (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [A323195E98A5]
http://linked.open...i/riv/nazevZdroje
  • Journal of Affective Disorders
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 121
http://linked.open...iv/tvurceVysledku
  • Hájek, Tomáš
  • Alda, M.
  • Duffy, Anne
  • Grof, Paul
  • Sherry, Simon B.
http://linked.open...ain/vavai/riv/wos
  • 000274360200017
issn
  • 0165-0327
number of pages
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