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  • OBJECTIVE: To describe and integrate observations from bipolar patients responsive to lithium stabilization and their children. METHOD: Selected findings are described from the clinical and biological investigations of adults meeting research criteria for bipolar disorder and for responsiveness to lithium stabilization; and from prospective studies of the children of lithium responders and non-responders. RESULTS: Response to prophylactic lithium identifies a valid subtype of bipolar disorder, however the search for biological markers of lithium response, while promising, has so far remained inconclusive. Adult responders to lithium stabilization exhibit definable clinical features which are also observable in their affected children. In prospective studies the children of bipolar parents develop symptoms earlier than reported previously, with marked differences between the offspring of lithium responders and non-responders. The illness evolves in predictable clinical stages, first from non-specific
  • OBJECTIVE: To describe and integrate observations from bipolar patients responsive to lithium stabilization and their children. METHOD: Selected findings are described from the clinical and biological investigations of adults meeting research criteria for bipolar disorder and for responsiveness to lithium stabilization; and from prospective studies of the children of lithium responders and non-responders. RESULTS: Response to prophylactic lithium identifies a valid subtype of bipolar disorder, however the search for biological markers of lithium response, while promising, has so far remained inconclusive. Adult responders to lithium stabilization exhibit definable clinical features which are also observable in their affected children. In prospective studies the children of bipolar parents develop symptoms earlier than reported previously, with marked differences between the offspring of lithium responders and non-responders. The illness evolves in predictable clinical stages, first from non-specific (en)
Title
  • Lithium response across generations
  • Lithium response across generations (en)
skos:prefLabel
  • Lithium response across generations
  • Lithium response across generations (en)
skos:notation
  • RIV/00023752:_____/09:00001035!RIV10-MZ0-00023752
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S, V
http://linked.open...iv/cisloPeriodika
  • 5
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 323940
http://linked.open...ai/riv/idVysledku
  • RIV/00023752:_____/09:00001035
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • bipolar disorders; offspring; children; lithium; long-term treatment; stabilization; clinical profile; responders; biological markers (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • DK - Dánské království
http://linked.open...ontrolniKodProRIV
  • [34644362A1EF]
http://linked.open...i/riv/nazevZdroje
  • Acta Psychiatrica Scandinavica
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 120
http://linked.open...iv/tvurceVysledku
  • Hájek, Tomáš
  • Alda, M.
  • Duffy, Anne
  • Grof, Paul
http://linked.open...ain/vavai/riv/wos
  • 000270586600007
issn
  • 0001-690X
number of pages
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