About: Heterogeneity of the risk of suicidal behavior in bipolar-spectrum disorders

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Toto je studie výskytu sebevražedneéo chování v rodinách pacientů s poruchou nálady. (cs) Objectives: The risk of suicidal behavior is substantially elevated in major affective disorders (AD). In bipolar disorder (BD), as many as 15% of patients may commit suicide and family history of suicide is recognized as one of the most important risk factors. Lithium reduces the rates of suicidal behavior in BD, especially in patients who achieve full mood stabilization. Yet even patients who continue experiencing mood episodes do benefit from anti-suicidal properties of lithium. These observations raise questions about the nature of the relationship between the neurobiological mechanisms of BD and suicide, namely whether they are shared or independent. Methods: We studied the distribution of suicides and suicide attempts in 539 subjects from 78 families of probands with major AD, all responders to lithium prophylaxis. A Cox proportional hazard regression model was used to assess the contribution of several independent variables to the risks of AD, BD, and suicidal behavior. Results: The lifetime pr Objectives: The risk of suicidal behavior is substantially elevated in major affective disorders (AD). In bipolar disorder (BD), as many as 15% of patients may commit suicide and family history of suicide is recognized as one of the most important risk factors. Lithium reduces the rates of suicidal behavior in BD, especially in patients who achieve full mood stabilization. Yet even patients who continue experiencing mood episodes do benefit from anti-suicidal properties of lithium. These observations raise questions about the nature of the relationship between the neurobiological mechanisms of BD and suicide, namely whether they are shared or independent. Methods: We studied the distribution of suicides and suicide attempts in 539 subjects from 78 families of probands with major AD, all responders to lithium prophylaxis. A Cox proportional hazard regression model was used to assess the contribution of several independent variables to the risks of AD, BD, and suicidal behavior. Results: The lifetime pr (en)
Title	Heterogeneity of the risk of suicidal behavior in bipolar-spectrum disorders Heterogeneita rizika sebevražedného chování u pacientů s bipolární poruchou (cs) Heterogeneity of the risk of suicidal behavior in bipolar-spectrum disorders (en)
skos:prefLabel	Heterogeneity of the risk of suicidal behavior in bipolar-spectrum disorders Heterogeneita rizika sebevražedného chování u pacientů s bipolární poruchou (cs) Heterogeneity of the risk of suicidal behavior in bipolar-spectrum disorders (en)
skos:notation	RIV/00023752:_____/07:00000787!RIV09-MZ0-00023752
http://linked.open...avai/riv/aktivita	N V
http://linked.open...avai/riv/aktivity	N, V
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Hájek, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Národní ústav duševního zdraví
http://linked.open...dnocenehoVysledku	424028
http://linked.open...ai/riv/idVysledku	RIV/00023752:_____/07:00000787
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	bipolar disorder; family study; lithium response; mood disorders; suicide (en)
http://linked.open.../riv/klicoveSlovo	suicide lithium response mood disorders bipolar disorder family study
http://linked.open...odStatuVydavatele	DK - Dánské království
http://linked.open...ontrolniKodProRIV	[F9D941A6CD83]
http://linked.open...i/riv/nazevZdroje	Bipolar Disorders
http://linked.open...in/vavai/riv/obor	FL
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Hájek, Tomáš Alda, M. Duffy, A. Grof, P. Robertson, C. Cavazzoni, P. Davis, A. Zvolský, P. Grof, E. Ahrens, B. Berghöfer, A. Müller-Oerlinghausen, B.
issn	1398-5647
number of pages	9 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Heterogeneity of the risk of suicidal behavior in bipolar-spectrum disorders Heterogeneity of the risk of suicidal behavior in bipolar-spectrum disorders Heterogeneity of the risk of suicidal behavior in bipolar-spectrum disorders

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