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  • The search for susceptibility genes for bipolar disorder (BD) depends on appropriate definitions of the phenotype. In this paper, we review data on diagnosis and clinical features of BD that could be used in genetic studies to better characterize patients or to define homogeneous subgroups. Clinical symptoms, long-term course, comorbid conditions, and response to prophylactic treatment may define groups associated with more or less specific loci. One such group is characterized by symptoms of psychosis and linkage to 13q and 22q. A second group includes mainly bipolar II patients with comorbid panic disorder, rapid mood switching, and evidence of chromosome 18 linkage. A third group comprises typical BD with an episodic course and favourable response to lithium prophylaxis. Reproducibility of cognitive deficits across studies raises the possibility of using cognitive profiles as endophenotypes of BD, with deficits in verbal explicit memory and executive function commonly reported. Brain imaging provid
  • The search for susceptibility genes for bipolar disorder (BD) depends on appropriate definitions of the phenotype. In this paper, we review data on diagnosis and clinical features of BD that could be used in genetic studies to better characterize patients or to define homogeneous subgroups. Clinical symptoms, long-term course, comorbid conditions, and response to prophylactic treatment may define groups associated with more or less specific loci. One such group is characterized by symptoms of psychosis and linkage to 13q and 22q. A second group includes mainly bipolar II patients with comorbid panic disorder, rapid mood switching, and evidence of chromosome 18 linkage. A third group comprises typical BD with an episodic course and favourable response to lithium prophylaxis. Reproducibility of cognitive deficits across studies raises the possibility of using cognitive profiles as endophenotypes of BD, with deficits in verbal explicit memory and executive function commonly reported. Brain imaging provid (en)
  • Souhrn: Článek podává přehled klinických, neurokognitivních a neuroanatomických nálezů, které by mohly sloužit k rozdělení pacientů na homogenní skupiny pro účely genetických analýz. (cs)
Title
  • The phenotypes of bipolar disorder: relevance for genetic investigations
  • Fenotyp bipolární poruchy: relevance pro genetické studie (cs)
  • The phenotypes of bipolar disorder: relevance for genetic investigations (en)
skos:prefLabel
  • The phenotypes of bipolar disorder: relevance for genetic investigations
  • Fenotyp bipolární poruchy: relevance pro genetické studie (cs)
  • The phenotypes of bipolar disorder: relevance for genetic investigations (en)
skos:notation
  • RIV/00023752:_____/05:00000880!RIV09-MZ0-00023752
http://linked.open...avai/riv/aktivita
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  • N, S
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  • 9
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  • 535889
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  • RIV/00023752:_____/05:00000880
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  • bipolar disorder; genetics; endophenotype; neurocognitive function; brain imaging (en)
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http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [62F14D46F557]
http://linked.open...i/riv/nazevZdroje
  • Molecular Psychiatry
http://linked.open...in/vavai/riv/obor
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http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 10
http://linked.open...iv/tvurceVysledku
  • Hájek, Tomáš
  • Alda, M.
  • MacQueen, G. M.
issn
  • 1359-4184
number of pages
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