About: Functional magnetic resonance (fMR) and serotonergic activity in the brain

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About: Functional magnetic resonance (fMR) and serotonergic activity in the brain Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of our study was to elucidate the relationship between central serotonergic activity and the outcome in cognitive testing within the framework of functional activity in the relevant brain regions. The interaction between serotonine and dopamine within mesolimbic and mesocortical areas probably represents the basic substrate for pathophysiology and therapy of schizophrenia. Methods: Tryptophan depletion method (in comparison with placebo) was used as the probe to the role of serotonine in cognition. Tryptophan is the precursor of serotonine and the tryptophan depletion decreases rapidly the level of brain serotonine. Functional Magnetic Resonance (fMR) is a sophisticated non-invasive neuroimaging method enabling to measure regional cerebral blood flow and elaborate dynamic functional maps of brain activity. fMR was used to detect the changes in neuronal activation in the brain with respect to different level of serotonergic transmission. Results: In the group of 20 healthy subjects we found the The aim of our study was to elucidate the relationship between central serotonergic activity and the outcome in cognitive testing within the framework of functional activity in the relevant brain regions. The interaction between serotonine and dopamine within mesolimbic and mesocortical areas probably represents the basic substrate for pathophysiology and therapy of schizophrenia. Methods: Tryptophan depletion method (in comparison with placebo) was used as the probe to the role of serotonine in cognition. Tryptophan is the precursor of serotonine and the tryptophan depletion decreases rapidly the level of brain serotonine. Functional Magnetic Resonance (fMR) is a sophisticated non-invasive neuroimaging method enabling to measure regional cerebral blood flow and elaborate dynamic functional maps of brain activity. fMR was used to detect the changes in neuronal activation in the brain with respect to different level of serotonergic transmission. Results: In the group of 20 healthy subjects we found the (en)
Title	Functional magnetic resonance (fMR) and serotonergic activity in the brain Functional magnetic resonance (fMR) and serotonergic activity in the brain (en)
skos:prefLabel	Functional magnetic resonance (fMR) and serotonergic activity in the brain Functional magnetic resonance (fMR) and serotonergic activity in the brain (en)
skos:notation	RIV/00023752:_____/02:00000246!RIV/2003/MZ0/L28003/N
http://linked.open.../vavai/riv/strany	19
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NF6033)
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Linhartová, Lucie Horáček, Jiří Kopeček, Miloslav Hájek, Tomáš Španiel, Filip
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Národní ústav duševního zdraví
http://linked.open...dnocenehoVysledku	646650
http://linked.open...ai/riv/idVysledku	RIV/00023752:_____/02:00000246
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Brain; serotonine; Schizophrenia; Tryptophan; cognition; fMR; neuroimaging; blood (en)
http://linked.open.../riv/klicoveSlovo	Schizophrenia Tryptophan serotonine fMR cognition neuroimaging blood Brain
http://linked.open...ontrolniKodProRIV	[3BCC439DA25C]
http://linked.open...v/mistoKonaniAkce	Častá
http://linked.open...i/riv/mistoVydani	Bratislava
http://linked.open...i/riv/nazevZdroje	X. International Congress of the Czech and Slovak Neurochemical Society, Casta, Slovakia, June 1-5, 2002
http://linked.open...in/vavai/riv/obor	FL
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	The deficit of cognitive function in scizophrenia and central serotonergic activity
http://linked.open...UplatneniVysledku	2002
http://linked.open...iv/tvurceVysledku	Horáček, Jiří Hájek, Tomáš Kopeček, Miloslav Španiel, Filip Závěšická, Lucie Tintěra, F.
http://linked.open.../riv/zahajeniAkce	2002-06-01 (xsd:date)
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	SAP - Slovak Academic Press

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