About: Characterisation of hippocampal neurodegeneration after intracerebroventricular administration of n-acetyl-aspartyl-glutamate

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About: Characterisation of hippocampal neurodegeneration after intracerebroventricular administration of n-acetyl-aspartyl-glutamate Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	N-Acetyl-aspartyl-glutamate (NAAG), the most abundant neuroactive peptide in the mammalian CNS, has only two known specific targets in brain tissue: ionotropic glutamate receptor of N-methyl-D-aspartate type and metabotropic G-protein linked glutamate receptors of class II. Several observations have pointed to a nexus between changes in the level of NAAG in brain and the development of neurodegenerative and mental diseases. The precise role of NAAG in neurodegeneration (or in healthy brain tissue) is, however, less clear. There could be a fine balance between the neuroprotective and neurotoxic actions of NAAG, depending on which one of the two populations of receptors targeted by NAAG is more active. The decisive factor could be the extracellular concentration (rather than overall tissue level) of NAAG and this can be manipulated in an animal model in vivo. Therefore, we have been using quantitative morphology, electron microscopy and molecular biological techniques to study and characterize the neuro N-Acetyl-aspartyl-glutamate (NAAG), the most abundant neuroactive peptide in the mammalian CNS, has only two known specific targets in brain tissue: ionotropic glutamate receptor of N-methyl-D-aspartate type and metabotropic G-protein linked glutamate receptors of class II. Several observations have pointed to a nexus between changes in the level of NAAG in brain and the development of neurodegenerative and mental diseases. The precise role of NAAG in neurodegeneration (or in healthy brain tissue) is, however, less clear. There could be a fine balance between the neuroprotective and neurotoxic actions of NAAG, depending on which one of the two populations of receptors targeted by NAAG is more active. The decisive factor could be the extracellular concentration (rather than overall tissue level) of NAAG and this can be manipulated in an animal model in vivo. Therefore, we have been using quantitative morphology, electron microscopy and molecular biological techniques to study and characterize the neuro (en)
Title	Characterisation of hippocampal neurodegeneration after intracerebroventricular administration of n-acetyl-aspartyl-glutamate Characterisation of hippocampal neurodegeneration after intracerebroventricular administration of n-acetyl-aspartyl-glutamate (en)
skos:prefLabel	Characterisation of hippocampal neurodegeneration after intracerebroventricular administration of n-acetyl-aspartyl-glutamate Characterisation of hippocampal neurodegeneration after intracerebroventricular administration of n-acetyl-aspartyl-glutamate (en)
skos:notation	RIV/00023752:_____/01:00000162!RIV/2002/MSM/L28002/N
http://linked.open.../vavai/riv/strany	102-104
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(LN00B122)
http://linked.open...iv/cisloPeriodika	Suppl. 2
http://linked.open...vai/riv/dodaniDat	2002
http://linked.open...aciTvurceVysledku	Šťastný, František Bubeníková-Valešová, Věra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Národní ústav duševního zdraví
http://linked.open...dnocenehoVysledku	675356
http://linked.open...ai/riv/idVysledku	RIV/00023752:_____/01:00000162
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	N-Acetyl-aspartyl-glutamate, glutamate, N-acetyl-aspartate, neurodegeneration, necrosis, apoptosis (en)
http://linked.open.../riv/klicoveSlovo	glutamate necrosis apoptosis neurodegeneration N-Acetyl-aspartyl-glutamate N-acetyl-aspartate
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[B3D83A44851A]
http://linked.open...i/riv/nazevZdroje	Psychiatrie
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Neuropsychiatric Research Center
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	5
http://linked.open...iv/tvurceVysledku	Šťastný, František Bubeníková, Věra Balcar, Vladimír Joseph Pliss, Lioudmila
issn	1211-7579
number of pages	3 (xsd:int)

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