About: Loss of adhesion/growth-regulatory galectin-9 from squamous cell epithelium in head and neck carcinomas

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About: Loss of adhesion/growth-regulatory galectin-9 from squamous cell epithelium in head and neck carcinomas Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org//10.1111/j.1600-0714.2012.01185.x
Description	Galectins are potent effectors of cell adhesion and growth regulation. Their expression as comples network necessitates systematic study of each member of this family. Toward this aim, we here focus on the tandem-repeat-type galectin-9. Its presence is monitored in normal squamous epithelium of the head and neck, the surgical margin, and four types of squamous cell carcinoma. Lectin presence was detected in cells of the basal layer of the epithelium. All galectin-9-negative epithelia showed aberrant positivity for keratins 14 and 19. The surgical margin presented either a normal pattern of galectin-9 and keratin presence or a mosaic-like presence/absence of galectin-9 and aberrant expression of both keratins 14 and 19. All studied specimens of squamous cell carcinoma were negative for galectin-9. When biotinylated galectin-9, or its N-terminal domain, was tested, no significant tissue reactivity for both probes was observed. Neuraminidase treatment generated reactivity to the N-domain. Galectins are potent effectors of cell adhesion and growth regulation. Their expression as comples network necessitates systematic study of each member of this family. Toward this aim, we here focus on the tandem-repeat-type galectin-9. Its presence is monitored in normal squamous epithelium of the head and neck, the surgical margin, and four types of squamous cell carcinoma. Lectin presence was detected in cells of the basal layer of the epithelium. All galectin-9-negative epithelia showed aberrant positivity for keratins 14 and 19. The surgical margin presented either a normal pattern of galectin-9 and keratin presence or a mosaic-like presence/absence of galectin-9 and aberrant expression of both keratins 14 and 19. All studied specimens of squamous cell carcinoma were negative for galectin-9. When biotinylated galectin-9, or its N-terminal domain, was tested, no significant tissue reactivity for both probes was observed. Neuraminidase treatment generated reactivity to the N-domain. (en)
Title	Loss of adhesion/growth-regulatory galectin-9 from squamous cell epithelium in head and neck carcinomas Loss of adhesion/growth-regulatory galectin-9 from squamous cell epithelium in head and neck carcinomas (en)
skos:prefLabel	Loss of adhesion/growth-regulatory galectin-9 from squamous cell epithelium in head and neck carcinomas Loss of adhesion/growth-regulatory galectin-9 from squamous cell epithelium in head and neck carcinomas (en)
skos:notation	RIV/00023736:_____/13:00009659!RIV14-MZ0-00023736
http://linked.open...avai/predkladatel	Ústav hematologie a krevní transfúze
http://linked.open...avai/riv/aktivita	I S V
http://linked.open...avai/riv/aktivity	I, S, V
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Tachezy, Ruth Foltynová, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	85442
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/13:00009659
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	agglutinin; basal cells; epithelium; keratin; lectin; tumor (en)
http://linked.open.../riv/klicoveSlovo	agglutinin basal cells keratin lectin tumor epithelium
http://linked.open...odStatuVydavatele	DK - Dánské království
http://linked.open...ontrolniKodProRIV	[D583C128E6AB]
http://linked.open...i/riv/nazevZdroje	Journal of oral pathology & medicine
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	42
http://linked.open...iv/tvurceVysledku	Valach, J. André, S. Gabius, H. J. Kaltner, H. Tachezy, Ruth Chovanec, M. Smetana, K. Kodet, R. Foltynová, Eva Fík, Z. Mazánek, J. Kodet, O.
http://linked.open...ain/vavai/riv/wos	000314471200008
issn	0904-2512
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/j.1600-0714.2012.01185.x

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