About: Monitoring of methylation changes in 9p21 region in patients with myelodysplastic syndromes and acute myeloid leukemia

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About: Monitoring of methylation changes in 9p21 region in patients with myelodysplastic syndromes and acute myeloid leukemia Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.4149/neo_2012_022
Description	Epigenetic de novo methylation of CpG islands is an important event in malignant transformation. Two genes are frequently methylated: cyclin-dependent kinase inhibitor 2B (CDKN2B) and cyclin-dependent kinase inhibitor 2A (CDKN2A). In our study methylation of these genes was studied in 63 patients with myelodysplastic syndromes (MDS), 2 with myelodysplastic/myeloproliferative neoplasms (MDS/MPN) and 13 with acute myeloid leukemia (AML). Five patients were monitored during 5-azacytidine treatment. Twenty-six healthy donors were tested in a control group. Epigenetic de novo methylation of CpG islands is an important event in malignant transformation. Two genes are frequently methylated: cyclin-dependent kinase inhibitor 2B (CDKN2B) and cyclin-dependent kinase inhibitor 2A (CDKN2A). In our study methylation of these genes was studied in 63 patients with myelodysplastic syndromes (MDS), 2 with myelodysplastic/myeloproliferative neoplasms (MDS/MPN) and 13 with acute myeloid leukemia (AML). Five patients were monitored during 5-azacytidine treatment. Twenty-six healthy donors were tested in a control group. (en)
Title	Monitoring of methylation changes in 9p21 region in patients with myelodysplastic syndromes and acute myeloid leukemia Monitoring of methylation changes in 9p21 region in patients with myelodysplastic syndromes and acute myeloid leukemia (en)
skos:prefLabel	Monitoring of methylation changes in 9p21 region in patients with myelodysplastic syndromes and acute myeloid leukemia Monitoring of methylation changes in 9p21 region in patients with myelodysplastic syndromes and acute myeloid leukemia (en)
skos:notation	RIV/00023736:_____/12:00009600!RIV13-MZ0-00023736
http://linked.open...avai/predkladatel	Ústav hematologie a krevní transfúze
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MZ0UHKT2005)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Čermák, Jaroslav Nováková, Ludmila Beličková, Monika Pegová, Kristýna Štemberková, Radka Čechová, Hana Jenčík, Ján Staňková, Martina Laššuthová, Petra Hrabáková, Pavla Říhová, Hana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	151659
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/12:00009600
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DNA methylation; CDKN2A; CDKN2B; 5-azacytidine; MS-MLPA (en)
http://linked.open.../riv/klicoveSlovo	CDKN2A CDKN2B 5-azacytidine MS-MLPA DNA methylation
http://linked.open...odStatuVydavatele	SK - Slovenská republika
http://linked.open...ontrolniKodProRIV	[35C0188D15F6]
http://linked.open...i/riv/nazevZdroje	Neoplasma
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	11 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	59
http://linked.open...iv/tvurceVysledku	Nováková, Ludmila Staňková, Martina Čechová, Hana Beličková, Monika Čermák, Jaroslav Laššuthová, Petra Hrabáková, Pavla Jenčík, Ján Pegová, Kristýna Štemberková, Radka Žižková, Hana
http://linked.open...ain/vavai/riv/wos	000301083700007
http://linked.open...n/vavai/riv/zamer	Význam molekulárně biologických vyšetření pro objasnění patogeneze a pro diagnostiku poruch krvetvorby a využití krvetvorné buňky v léčbě onemocnění krvetvorby a jiných tkání.
issn	0028-2685
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.4149/neo_2012_022
is http://linked.open...avai/riv/vysledek of	Monitoring of methylation changes in 9p21 region in patients with myelodysplastic syndromes and acute myeloid leukemia

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