About: Epigenetic modulation of gene expression of human leukemia cell lines

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About: Epigenetic modulation of gene expression of human leukemia cell lines - induction of cell death and senescence Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.4149/neo_2011_01_35
Description	Histone deacetylase inhibitors (HDACi) are emerging new class of anticancer agents that act by inhibiting cell growth, inducing cell cycle arrest and apoptosis of various cancer cells. However, in some conditions, apoptosis can be blocked and non apoptotic cell death and irreversible growth arrest, namely senescence, can be activated as potential tumor-suppressor mechanism. Here we evaluated the dosage effects of HDAC inhibitors suberoylanilide hydroxamic acid (SAHA) and valproic acid (VPA) in a series of human leukaemia cell lines. Histone deacetylase inhibitors (HDACi) are emerging new class of anticancer agents that act by inhibiting cell growth, inducing cell cycle arrest and apoptosis of various cancer cells. However, in some conditions, apoptosis can be blocked and non apoptotic cell death and irreversible growth arrest, namely senescence, can be activated as potential tumor-suppressor mechanism. Here we evaluated the dosage effects of HDAC inhibitors suberoylanilide hydroxamic acid (SAHA) and valproic acid (VPA) in a series of human leukaemia cell lines. (en)
Title	Epigenetic modulation of gene expression of human leukemia cell lines - induction of cell death and senescence Epigenetic modulation of gene expression of human leukemia cell lines - induction of cell death and senescence (en)
skos:prefLabel	Epigenetic modulation of gene expression of human leukemia cell lines - induction of cell death and senescence Epigenetic modulation of gene expression of human leukemia cell lines - induction of cell death and senescence (en)
skos:notation	RIV/00023736:_____/11:00009155!RIV12-MZ0-00023736
http://linked.open...avai/predkladatel	Ústav hematologie a krevní transfúze
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MZ0UHKT2005)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Elknerová, Klára Stöckbauer, Petr Myslivcová, Denisa Uherková, Lenka Lacinová, Zuzana Marinov, Iuri
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	197827
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/11:00009155
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	senescence; apoptosis; histone deacetylase inhibitors (HDACi); suberoylanilide hydroxamic acid (SAHA); valproic acid (VPA) (en)
http://linked.open.../riv/klicoveSlovo	histone deacetylase inhibitors (HDACi) suberoylanilide hydroxamic acid (SAHA) valproic acid (VPA) senescence apoptosis
http://linked.open...odStatuVydavatele	SK - Slovenská republika
http://linked.open...ontrolniKodProRIV	[5E8451482F5F]
http://linked.open...i/riv/nazevZdroje	Neoplasma
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	58
http://linked.open...iv/tvurceVysledku	Marinov, Iuri Elknerová, Klára Lacinová, Zuzana Myslivcová, Denisa Stöckbauer, Petr Uherková, Lenka
http://linked.open...ain/vavai/riv/wos	000290695500006
http://linked.open...n/vavai/riv/zamer	Význam molekulárně biologických vyšetření pro objasnění patogeneze a pro diagnostiku poruch krvetvorby a využití krvetvorné buňky v léčbě onemocnění krvetvorby a jiných tkání.
issn	0028-2685
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.4149/neo_2011_01_35
is http://linked.open...avai/riv/vysledek of	Epigenetic modulation of gene expression of human leukemia cell lines - induction of cell death and senescence Epigenetic modulation of gene expression of human leukemia cell lines - induction of cell death and senescence

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