About: Distinctive microRNA expression profiles in CD34+ bone marrow cells from patients with myelodysplastic syndrome

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	MicroRNAs (miRNAs) are small non-coding RNAs functioning as regulators of hematopoiesis. Their differential expression patterns have been linked with various pathological processes originating from hematopoietic stem cells (HSCs). However, limited information is available regarding the role of miRNAs in myelodysplastic syndrome (MDS). Using miRNA arrays, we measured expression of 1,145 miRNAs in CD34+ bone marrow cells obtained from 39 MDS and acute myeloid leukemia (AML) evolved from MDS patients, and compared them with those of six healthy donors. Differential miRNA expression was analyzed and a panel of upregulated (n=13) and downregulated (n=9) miRNAs were found (P<0.001) in MDS/AML patients. An increased expression of a large miRNA cluster mapped within the 14q32 locus was detected. MicroRNAs (miRNAs) are small non-coding RNAs functioning as regulators of hematopoiesis. Their differential expression patterns have been linked with various pathological processes originating from hematopoietic stem cells (HSCs). However, limited information is available regarding the role of miRNAs in myelodysplastic syndrome (MDS). Using miRNA arrays, we measured expression of 1,145 miRNAs in CD34+ bone marrow cells obtained from 39 MDS and acute myeloid leukemia (AML) evolved from MDS patients, and compared them with those of six healthy donors. Differential miRNA expression was analyzed and a panel of upregulated (n=13) and downregulated (n=9) miRNAs were found (P<0.001) in MDS/AML patients. An increased expression of a large miRNA cluster mapped within the 14q32 locus was detected. (en)
Title	Distinctive microRNA expression profiles in CD34+ bone marrow cells from patients with myelodysplastic syndrome Distinctive microRNA expression profiles in CD34+ bone marrow cells from patients with myelodysplastic syndrome (en)
skos:prefLabel	Distinctive microRNA expression profiles in CD34+ bone marrow cells from patients with myelodysplastic syndrome Distinctive microRNA expression profiles in CD34+ bone marrow cells from patients with myelodysplastic syndrome (en)
skos:notation	RIV/00023736:_____/11:00008921!RIV11-GA0-00023736
http://linked.open...avai/predkladatel	Ústav hematologie a krevní transfúze
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GP301/09/P579), Z(MZ0UHKT2005)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Krejčík, Zdeněk Čermák, Jaroslav Dostálová Merkerová, Michaela Vašíková, Alžběta Votavová, Hana Beličková, Monika
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	194892
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/11:00008921
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	miRNA; hematopoiesis; MDS (en)
http://linked.open.../riv/klicoveSlovo	hematopoiesis miRNA MDS
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[0B31CBBEBD63]
http://linked.open...i/riv/nazevZdroje	European Journal of Human Genetics
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Importance of miRNA deregulation in myelodysplastic syndromes and in other hematological clonal diseases
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	19
http://linked.open...iv/tvurceVysledku	Beličková, Monika Dostálová Merkerová, Michaela Vašíková, Alžběta Votavová, Hana Čermák, Jaroslav Krejčík, Zdeněk
http://linked.open...ain/vavai/riv/wos	000287445600017
http://linked.open...n/vavai/riv/zamer	Význam molekulárně biologických vyšetření pro objasnění patogeneze a pro diagnostiku poruch krvetvorby a využití krvetvorné buňky v léčbě onemocnění krvetvorby a jiných tkání.
issn	1018-4813
number of pages	7 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Distinctive microRNA expression profiles in CD34+ bone marrow cells from patients with myelodysplastic syndrome Distinctive microRNA expression profiles in CD34+ bone marrow cells from patients with myelodysplastic syndrome

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