About: MicroRNA expression profiles in umbilical cord blood cell lineages

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	MicroRNAs (miRNAs), important regulators of cellular processes, show specific expression signatures in different blood cell lineages and stages of hematopoietic stem cell (HSC) differentiation, indicating their role in the control of hematopoiesis. Because neonatal blood displays various features of immaturity, we might expect differential miRNA regulation. Herein, we determined miRNA expression profiles of umbilical cord blood (UCB) cell lineages and compared them to those of bone marrow (BM) and peripheral blood (PB) cell counterparts. Further, an approach combining bioinformatic prediction of miRNA targets with mRNA expression profiling was used to search for putative targets of miRNAs with potential functions in UCB. We pointed out several differentially expressed miRNAs and associated their expression with the target transcript levels. MicroRNAs (miRNAs), important regulators of cellular processes, show specific expression signatures in different blood cell lineages and stages of hematopoietic stem cell (HSC) differentiation, indicating their role in the control of hematopoiesis. Because neonatal blood displays various features of immaturity, we might expect differential miRNA regulation. Herein, we determined miRNA expression profiles of umbilical cord blood (UCB) cell lineages and compared them to those of bone marrow (BM) and peripheral blood (PB) cell counterparts. Further, an approach combining bioinformatic prediction of miRNA targets with mRNA expression profiling was used to search for putative targets of miRNAs with potential functions in UCB. We pointed out several differentially expressed miRNAs and associated their expression with the target transcript levels. (en)
Title	MicroRNA expression profiles in umbilical cord blood cell lineages MicroRNA expression profiles in umbilical cord blood cell lineages (en)
skos:prefLabel	MicroRNA expression profiles in umbilical cord blood cell lineages MicroRNA expression profiles in umbilical cord blood cell lineages (en)
skos:notation	RIV/00023736:_____/10:00008242!RIV10-MZ0-00023736
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NR9236)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Dostálová Merkerová, Michaela Vašíková, Alžběta Votavová, Hana Beličková, Monika
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	271241
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/10:00008242
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	umbilical cord blood; microRNA expression; mRNA profiles; potential target genes (en)
http://linked.open.../riv/klicoveSlovo	mRNA profiles microRNA expression potential target genes umbilical cord blood
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[3BB6706CCC92]
http://linked.open...i/riv/nazevZdroje	Stem cells and development
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Endogeneous post-transcriptional regulation of gene function by miRNA
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	19
http://linked.open...iv/tvurceVysledku	Beličková, Monika Vašíková, Alžběta Merkerová, Michaela Bruchová, Hana
http://linked.open...ain/vavai/riv/wos	000273675300003
issn	1547-3287
number of pages	8 (xsd:int)
is http://linked.open...avai/riv/vysledek of	MicroRNA expression profiles in umbilical cord blood cell lineages MicroRNA expression profiles in umbilical cord blood cell lineages MicroRNA expression profiles in umbilical cord blood cell lineages

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