About: Differential gene expression of bone marrow CD34+ cells in early and advanced myelodysplastic syndrome

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About: Differential gene expression of bone marrow CD34+ cells in early and advanced myelodysplastic syndrome Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Myelodysplastic syndrome (MDS) is a hematopoietic stem cell disorder characterized by ineffective hematopoiesis and dysplasia in one or more blood cell lines. Our study identified several differentially expressed genes using microarrays between early and advanced MDS patients. Expression levels of ADAM8, BIRC5 and MPL were validated in additional set of 29 patients using qRT-PCR. Their specific expression pattern was confirmed: higher expression of ADAM8 and MPL and lower expression of BIRC5 in advanced MDS compared to early MDS patients. Myelodysplastic syndrome (MDS) is a hematopoietic stem cell disorder characterized by ineffective hematopoiesis and dysplasia in one or more blood cell lines. Our study identified several differentially expressed genes using microarrays between early and advanced MDS patients. Expression levels of ADAM8, BIRC5 and MPL were validated in additional set of 29 patients using qRT-PCR. Their specific expression pattern was confirmed: higher expression of ADAM8 and MPL and lower expression of BIRC5 in advanced MDS compared to early MDS patients. (en)
Title	Differential gene expression of bone marrow CD34+ cells in early and advanced myelodysplastic syndrome Differential gene expression of bone marrow CD34+ cells in early and advanced myelodysplastic syndrome (en)
skos:prefLabel	Differential gene expression of bone marrow CD34+ cells in early and advanced myelodysplastic syndrome Differential gene expression of bone marrow CD34+ cells in early and advanced myelodysplastic syndrome (en)
skos:notation	RIV/00023736:_____/09:00008185!RIV10-MZ0-00023736
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NR9235), Z(MZ0UHKT2005)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Čermák, Jaroslav Vašíková, Alžběta Votavová, Hana Beličková, Monika
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	310494
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/09:00008185
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	MDS; expression profiles; CD34 (en)
http://linked.open.../riv/klicoveSlovo	CD34 expression profiles MDS
http://linked.open...odStatuVydavatele	SK - Slovenská republika
http://linked.open...ontrolniKodProRIV	[13943982B6E1]
http://linked.open...i/riv/nazevZdroje	Neoplasma
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	INVESTIGATION OF GENE EXPRESSION PROFILING IN PATIENTS WITH MYELODYSPLASTIC SYNDROME
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	56
http://linked.open...iv/tvurceVysledku	Beličková, Monika Vašíková, Alžběta Čermák, Jaroslav Bruchová, Hana Budinská, E.
http://linked.open...ain/vavai/riv/wos	000271991100009
http://linked.open...n/vavai/riv/zamer	Význam molekulárně biologických vyšetření pro objasnění patogeneze a pro diagnostiku poruch krvetvorby a využití krvetvorné buňky v léčbě onemocnění krvetvorby a jiných tkání.
issn	0028-2685
number of pages	8 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Differential gene expression of bone marrow CD34+ cells in early and advanced myelodysplastic syndrome Differential gene expression of bone marrow CD34+ cells in early and advanced myelodysplastic syndrome Differential gene expression of bone marrow CD34+ cells in early and advanced myelodysplastic syndrome Differential gene expression of bone marrow CD34+ cells in early and advanced myelodysplastic syndrome

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