About: Expression analysis of PCNA gene in chronic myelogenous leukemia : combined application of siRNA silencing and expression arrays

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	V předchozích publikacích jsme prokázali silnou up-regulaci genu PCNA u chronické myeloidní leukemie (CML). Kvůli studiu role PCNA v patogenezi CML jsme tlumili expresi PCNA pomocí siRNA a následně prováděli čipové experimenty Inhibice PCNA vedla k deregulaci několika genů spojených s buněčným cyklem, apoptózou a transformací. Protože však PCNA ovlivňuje proliferaci leukemických, ale i přirozeně proliferujících buněk, zdá se, že PCNA hraje sekundární roli vzhledem k proliferační aktivitě leukemických buněk (cs) Previously, we demonstrated strong PCNA up-regulation in chronic myelogenous leukemia (CML) patients. To further study its role in CML pathogenesis, we performed silencing of PCNA expression followed by array experiments. PCNA inhibition led to deregulation of several genes connected to cell cycle, apoptosis, and transformation. However, as PCNA affects cell growth in naturally proliferating cells as well as in cancerous cells, it seems to act a secondary role relating to proliferation activity of leukemic cells Previously, we demonstrated strong PCNA up-regulation in chronic myelogenous leukemia (CML) patients. To further study its role in CML pathogenesis, we performed silencing of PCNA expression followed by array experiments. PCNA inhibition led to deregulation of several genes connected to cell cycle, apoptosis, and transformation. However, as PCNA affects cell growth in naturally proliferating cells as well as in cancerous cells, it seems to act a secondary role relating to proliferation activity of leukemic cells (en)
Title	Expression analysis of PCNA gene in chronic myelogenous leukemia : combined application of siRNA silencing and expression arrays Expresní analýza genu PCNA u chronické myeloidní leukemie - kombinované využití siRNA techniky a expresních čipů (cs) Expression analysis of PCNA gene in chronic myelogenous leukemia : combined application of siRNA silencing and expression arrays (en)
skos:prefLabel	Expression analysis of PCNA gene in chronic myelogenous leukemia : combined application of siRNA silencing and expression arrays Expresní analýza genu PCNA u chronické myeloidní leukemie - kombinované využití siRNA techniky a expresních čipů (cs) Expression analysis of PCNA gene in chronic myelogenous leukemia : combined application of siRNA silencing and expression arrays (en)
skos:notation	RIV/00023736:_____/07:00007109!RIV08-MZ0-00023736
http://linked.open.../vavai/riv/strany	661;674
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NR7989)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Brdička, Radim Dostálová Merkerová, Michaela Votavová, Hana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	421400
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/07:00007109
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cell cycle; CML; electroporation; nucleofection; PCNA; proliferation; siRNA (en)
http://linked.open.../riv/klicoveSlovo	CML electroporation siRNA cell cycle proliferation nucleofection PCNA
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[5709D10FA78D]
http://linked.open...i/riv/nazevZdroje	Leukemia Research
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Targeted gene silencing using siRNAs in primary cell cultures of CML patients and leukemic cell lines (K562, MOLM-7, KU-812)
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	31
http://linked.open...iv/tvurceVysledku	Brdička, Radim Merkerová, Michaela Bruchová, Hana
issn	0145-2126
number of pages	4 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Expression analysis of PCNA gene in chronic myelogenous leukemia : combined application of siRNA silencing and expression arrays Expression analysis of PCNA gene in chronic myelogenous leukemia : combined application of siRNA silencing and expression arrays Expression analysis of PCNA gene in chronic myelogenous leukemia : combined application of siRNA silencing and expression arrays

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