About: Elevated thrombopoietin levels and alterations in the sequence of its receptor, c-Mpl, in patients with Diamond-Blackfan anemia.

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About: Elevated thrombopoietin levels and alterations in the sequence of its receptor, c-Mpl, in patients with Diamond-Blackfan anemia. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Studium možné účasti trombopoetinu (TPO) a jeho receptoru c-Mpl na patogenezi Diamondovy-Blackfanovy anémie (DBA) přineslo dva zajímavé výsledky. U 7/14 DBA pacientů byla opakovaně identifikována zvýšená hladina sérového TPO a u 3/14 pacientů byly nalezeny změny v genu pro c-Mpl. Zatímco zvýšená hladina TPO může představovat mechanizmus kompenzující narušenou erytropoézu, mutace v c-Mpl by mohly negativně ovlivňovat průběh onemocnění. (cs) In the study of the possible thrombopoietin (TPO)-c-Mpl pathway involvement in the pathogenesis of Diamond-Blackfan anemia, repeatedly increased serum TPO levels were identified in 7/14 patients and changes in c-mpl sequence in 3/14 patients. While elevated TPO levels can represent a compensatory mechanism for impaired erythropoiesis, c-Mpl mutations could influence the disease severity. In the study of the possible thrombopoietin (TPO)-c-Mpl pathway involvement in the pathogenesis of Diamond-Blackfan anemia, repeatedly increased serum TPO levels were identified in 7/14 patients and changes in c-mpl sequence in 3/14 patients. While elevated TPO levels can represent a compensatory mechanism for impaired erythropoiesis, c-Mpl mutations could influence the disease severity. (en)
Title	Elevated thrombopoietin levels and alterations in the sequence of its receptor, c-Mpl, in patients with Diamond-Blackfan anemia. Elevated thrombopoietin levels and alterations in the sequence of its receptor, c-Mpl, in patients with Diamond-Blackfan anemia. (en) Zvýšená hladina trombopoietinu a změny v genu pro c-Mpl u pacientů s Diamond-Blackfanovou anémií. (cs)
skos:prefLabel	Elevated thrombopoietin levels and alterations in the sequence of its receptor, c-Mpl, in patients with Diamond-Blackfan anemia. Elevated thrombopoietin levels and alterations in the sequence of its receptor, c-Mpl, in patients with Diamond-Blackfan anemia. (en) Zvýšená hladina trombopoietinu a změny v genu pro c-Mpl u pacientů s Diamond-Blackfanovou anémií. (cs)
skos:notation	RIV/00023736:_____/04:G0000017!RIV/2005/GA0/L33005/N
http://linked.open.../vavai/riv/strany	1391-1392
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GP301/04/P199)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Čmejlová, Jana Čmejla, Radek
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	562683
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/04:G0000017
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Diamond-Blackfan anemia;thrombopoietin;c-Mpl (en)
http://linked.open.../riv/klicoveSlovo	c-Mpl thrombopoietin Diamond-Blackfan anemia
http://linked.open...odStatuVydavatele	IT - Italská republika
http://linked.open...ontrolniKodProRIV	[066DF9EA0E3F]
http://linked.open...i/riv/nazevZdroje	Haematologica
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Analysis of genetic background of Diamond-Blackfan anemia
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	89
http://linked.open...iv/tvurceVysledku	Pospíšilová, D. Slavík, L. Lmejlová, Jana Lmejla, Radek
issn	0390-6078
number of pages	2 (xsd:int)

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