About: Histomorphometric changes by teriparatide in alendronate-pretreated women with osteoporosis

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About: Histomorphometric changes by teriparatide in alendronate-pretreated women with osteoporosis Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Bone anabolic effects of teriparatide (TPTD, rhPTH (1-34) in postmenopausal women with osteoporosis may be blunted by previous exposure of bone to alendronate (ALN). Paired biopsies were obtained after tetracycline double labeling at baseline and after 24 months of TPTD treatment from 29 ALN-pretreated (64.5 +/- 16.4 months) and 16 treatment naïve patients (TN). Biochemical markers were measured at baseline, during the treatment, or at study end. The level of increased bone formation after 24 months of treatment with TPTD was similar in patients who were either treatment-naive or had lower bone turnover initially due to previous alendronate therapy. Elevated bone formation in postmenopausal women with osteoporosis was sustained over a 24-month period by TPTD. Biochemical markers of bone formation are a good surrogate for the assessment of TPTD effects. Bone anabolic effects of teriparatide (TPTD, rhPTH (1-34) in postmenopausal women with osteoporosis may be blunted by previous exposure of bone to alendronate (ALN). Paired biopsies were obtained after tetracycline double labeling at baseline and after 24 months of TPTD treatment from 29 ALN-pretreated (64.5 +/- 16.4 months) and 16 treatment naïve patients (TN). Biochemical markers were measured at baseline, during the treatment, or at study end. The level of increased bone formation after 24 months of treatment with TPTD was similar in patients who were either treatment-naive or had lower bone turnover initially due to previous alendronate therapy. Elevated bone formation in postmenopausal women with osteoporosis was sustained over a 24-month period by TPTD. Biochemical markers of bone formation are a good surrogate for the assessment of TPTD effects. (en)
Title	Histomorphometric changes by teriparatide in alendronate-pretreated women with osteoporosis Histomorphometric changes by teriparatide in alendronate-pretreated women with osteoporosis (en)
skos:prefLabel	Histomorphometric changes by teriparatide in alendronate-pretreated women with osteoporosis Histomorphometric changes by teriparatide in alendronate-pretreated women with osteoporosis (en)
skos:notation	RIV/00023728:_____/10:#0000091!RIV11-MZ0-00023728
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Štěpán, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Revmatologický ústav
http://linked.open...dnocenehoVysledku	261636
http://linked.open...ai/riv/idVysledku	RIV/00023728:_____/10:#0000091
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Aged; Aminobisphosphonates; Markers; Bone Remodeling; Osteoporosis; Parathyroid Hormone (en)
http://linked.open.../riv/klicoveSlovo	Aminobisphosphonates Bone Remodeling Parathyroid Hormone Osteoporosis Aged Markers
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[8998028A1D9B]
http://linked.open...i/riv/nazevZdroje	Osteoporosis International
http://linked.open...in/vavai/riv/obor	FE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	21
http://linked.open...iv/tvurceVysledku	Li, J. Štěpán, Jan Michalská, Dana Dobnig, H. Burr, D. B. Fahrleitner-Pammer, A. Ma, Y. L. Pavo, I. Petto, H. Sipos, A.
http://linked.open...ain/vavai/riv/wos	285306900007
issn	0937-941X
number of pages	6 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Histomorphometric changes by teriparatide in alendronate-pretreated women with osteoporosis Histomorphometric changes by teriparatide in alendronate-pretreated women with osteoporosis Histomorphometric changes by teriparatide in alendronate-pretreated women with osteoporosis

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