About: Response to Comparison of Teriparatide and Strontium Ranelate in Postmenopausal Women with Osteoporosis

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The statistically significant reductions compared to baseline in serum PINP and ß-CTx in the SrR group indicate a weak inhibition of bone turnover activity at the dose used in humans and should be taken into account when analyzing the different effects of these two drugs on the bone remodeling cycle using bone biopsies. Changes in microarchitecture induced by SrR in human biopsies cannot be considered as proof of the anabolic effects of this drug, at least at the doses used in humans. These analyses were cross-sectional and not based on paired biopsies. The microstructural differences seen from µCT of iliac bone biopsies from SrR and placebo treated women were very similar to those described with classical antiresorptives such as alendronate and zoledronate in similar cross-sectional analyses The statistically significant reductions compared to baseline in serum PINP and ß-CTx in the SrR group indicate a weak inhibition of bone turnover activity at the dose used in humans and should be taken into account when analyzing the different effects of these two drugs on the bone remodeling cycle using bone biopsies. Changes in microarchitecture induced by SrR in human biopsies cannot be considered as proof of the anabolic effects of this drug, at least at the doses used in humans. These analyses were cross-sectional and not based on paired biopsies. The microstructural differences seen from µCT of iliac bone biopsies from SrR and placebo treated women were very similar to those described with classical antiresorptives such as alendronate and zoledronate in similar cross-sectional analyses (en)
Title	Response to Comparison of Teriparatide and Strontium Ranelate in Postmenopausal Women with Osteoporosis Response to Comparison of Teriparatide and Strontium Ranelate in Postmenopausal Women with Osteoporosis (en)
skos:prefLabel	Response to Comparison of Teriparatide and Strontium Ranelate in Postmenopausal Women with Osteoporosis Response to Comparison of Teriparatide and Strontium Ranelate in Postmenopausal Women with Osteoporosis (en)
skos:notation	RIV/00023728:_____/09:00000097!RIV10-MZ0-00023728
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Štěpán, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Revmatologický ústav
http://linked.open...dnocenehoVysledku	339185
http://linked.open...ai/riv/idVysledku	RIV/00023728:_____/09:00000097
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Biological Markers; Bone Remodeling; Osteoporosis; Strontium ranelate; Teriparatide (en)
http://linked.open.../riv/klicoveSlovo	Biological Markers Bone Remodeling Strontium ranelate Osteoporosis Teriparatide
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[68FC30FC6AB1]
http://linked.open...i/riv/nazevZdroje	Journal of Bone and Mineral Research
http://linked.open...in/vavai/riv/obor	FE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	24
http://linked.open...iv/tvurceVysledku	Štěpán, Jan Marin, F. Recker, R. R. Hawkins, F. Ish-Shalom, S.
http://linked.open...ain/vavai/riv/wos	000273216600018
issn	0884-0431
number of pages	2 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Response to Comparison of Teriparatide and Strontium Ranelate in Postmenopausal Women with Osteoporosis Response to Comparison of Teriparatide and Strontium Ranelate in Postmenopausal Women with Osteoporosis Response to Comparison of Teriparatide and Strontium Ranelate in Postmenopausal Women with Osteoporosis Response to Comparison of Teriparatide and Strontium Ranelate in Postmenopausal Women with Osteoporosis

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