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| Description
| - We examined the effects of angiotensin II AT(1)-receptor blockade with olmesartan on high fat (HF) diet-induced vascular oxidative stress and endothelial dysfunction in normal salt (NS) diet-fed Dahl salt-sensitive (DSS) rats. Treatment with NS + HF diet (32% crude fat, 0.3% NaCl) for 20 weeks significantly increased blood pressure in DSS rats. NS + HF diet-fed DSS rats also showed higher plasma levels of thiobarbituric acid reactive substances, aortic superoxide production, and mRNA levels of p22(phox) and gp91(phox) in aortic tissues than NS diet-fed DSS rats. Furthennore, acetylcholine-induced vasorelaxation of aorta from NS + HF diet-fed DSS rats was significantly reduced. In NS + HF diet-fed DSS rats, treatment with olmesartan medoxomil (10 mg/kg per day, p.o.) and hydralazine (25 mg/kg per day, p.o.) similarly decreased blood pressure. However, in these animals, only olmesartan normalized plasma levels of thiobarbituric acid-reactive substances, vascular superoxide in aortic tissues, and acetylcholine-induced vasorelaxation. These data indicate that HF diet-induced hypertension is associated with vascular oxidative stress and endothelial dysfunction in NS diet-treated DSS rats Inhibition of angiotensin II AT(1) receptors may elicit beneficial effects on HF-induced hypertension and vascular injury in subjects that have genetically enhanced sodium-sensitive blood pressure.
- We examined the effects of angiotensin II AT(1)-receptor blockade with olmesartan on high fat (HF) diet-induced vascular oxidative stress and endothelial dysfunction in normal salt (NS) diet-fed Dahl salt-sensitive (DSS) rats. Treatment with NS + HF diet (32% crude fat, 0.3% NaCl) for 20 weeks significantly increased blood pressure in DSS rats. NS + HF diet-fed DSS rats also showed higher plasma levels of thiobarbituric acid reactive substances, aortic superoxide production, and mRNA levels of p22(phox) and gp91(phox) in aortic tissues than NS diet-fed DSS rats. Furthennore, acetylcholine-induced vasorelaxation of aorta from NS + HF diet-fed DSS rats was significantly reduced. In NS + HF diet-fed DSS rats, treatment with olmesartan medoxomil (10 mg/kg per day, p.o.) and hydralazine (25 mg/kg per day, p.o.) similarly decreased blood pressure. However, in these animals, only olmesartan normalized plasma levels of thiobarbituric acid-reactive substances, vascular superoxide in aortic tissues, and acetylcholine-induced vasorelaxation. These data indicate that HF diet-induced hypertension is associated with vascular oxidative stress and endothelial dysfunction in NS diet-treated DSS rats Inhibition of angiotensin II AT(1) receptors may elicit beneficial effects on HF-induced hypertension and vascular injury in subjects that have genetically enhanced sodium-sensitive blood pressure. (en)
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| Title
| - Effects of Angiotensin II AT(1)-Receptor Blockade on High Fat Diet-Induced Vascular Oxidative Stress and Endothelial Dysfunction in Dahl Salt-Sensitive Rats
- Effects of Angiotensin II AT(1)-Receptor Blockade on High Fat Diet-Induced Vascular Oxidative Stress and Endothelial Dysfunction in Dahl Salt-Sensitive Rats (en)
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| skos:prefLabel
| - Effects of Angiotensin II AT(1)-Receptor Blockade on High Fat Diet-Induced Vascular Oxidative Stress and Endothelial Dysfunction in Dahl Salt-Sensitive Rats
- Effects of Angiotensin II AT(1)-Receptor Blockade on High Fat Diet-Induced Vascular Oxidative Stress and Endothelial Dysfunction in Dahl Salt-Sensitive Rats (en)
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| skos:notation
| - RIV/00023001:_____/13:00058535!RIV14-MZ0-00023001
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| http://linked.open...avai/predkladatel
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00023001:_____/13:00058535
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - angiotensin II (AngII); endothelial dysfunction; oxidative stress; Dahl salt-sensitive (DSS) rat; high fat (HF) diet (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Journal of pharmacological sciences
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Červenka, Luděk
- Nishiyama, Akira
- Fukuoka, Noriyasu
- Hitomi, Hirofumi
- Houchi, Hitoshi
- Kobara, Hideki
- Kobori, Hiroyuki
- Kosaka, Shinji
- Masaki, Tsutomu
- Matsumura, Yasuo
- Mori, Hirohito
- Nakano, Daisuke
- Pelisch, Nicolas
- Rahman, Matlubur
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| http://linked.open...ain/vavai/riv/wos
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| issn
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| number of pages
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| http://bibframe.org/vocab/doi
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