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| Description
| - Background:The presence of cardiovascular risk factors during the menopausal transition could be critical in the development of atherosclerosis. In the present study, we evaluated whether the menopausal transition has impact on traditional and newly discussed risk factors. Methods: 699 women from population-based study underwent ultrasound measurement of the intima-media thickeness of the common carotid arteries(CIMT) - Prague Pre and Postmenopausal Females study(3PMFs). In addition, 40 women selected according to reproductive and smoking status were examined with regard to number of circulating endothelial progenitor cells, markers of reverse cholesterol transport and sex hormones, including their fluctuation - Hormone Variability study/HVs). Results:Age, smoking, body mass index, systolic blood pressure and HDL cholesterol were independently associated with CIMT in 3PMFs group. The increase in the CIMT with age was markedlly steeper in curent/past smokers than in non-smokers among perimenopausal women (p for equality of slopes=0,005). This difference was not observed in premenopausal and menopausal women.In the HVs group, endothelial progenitor cells and reverse cholesterol transport were substanially higher while triglycerides and fluctuation of free testosterone were lower in non-smokers than in smokers in menopausal transition. In contrast, in menopausal women, the fluctuation of free testosterone was higher non-smokers; on other differences between smokers and non-smokers werw detected. Conlusions: These results suggest that atherosclerogenic effect of smoking may be enhanced during menopausal trastition. The mechanism could be impaired reparative vascular processes, impaired reverse cholesterol transport and rapidly changing status of sex hormones.
- Background:The presence of cardiovascular risk factors during the menopausal transition could be critical in the development of atherosclerosis. In the present study, we evaluated whether the menopausal transition has impact on traditional and newly discussed risk factors. Methods: 699 women from population-based study underwent ultrasound measurement of the intima-media thickeness of the common carotid arteries(CIMT) - Prague Pre and Postmenopausal Females study(3PMFs). In addition, 40 women selected according to reproductive and smoking status were examined with regard to number of circulating endothelial progenitor cells, markers of reverse cholesterol transport and sex hormones, including their fluctuation - Hormone Variability study/HVs). Results:Age, smoking, body mass index, systolic blood pressure and HDL cholesterol were independently associated with CIMT in 3PMFs group. The increase in the CIMT with age was markedlly steeper in curent/past smokers than in non-smokers among perimenopausal women (p for equality of slopes=0,005). This difference was not observed in premenopausal and menopausal women.In the HVs group, endothelial progenitor cells and reverse cholesterol transport were substanially higher while triglycerides and fluctuation of free testosterone were lower in non-smokers than in smokers in menopausal transition. In contrast, in menopausal women, the fluctuation of free testosterone was higher non-smokers; on other differences between smokers and non-smokers werw detected. Conlusions: These results suggest that atherosclerogenic effect of smoking may be enhanced during menopausal trastition. The mechanism could be impaired reparative vascular processes, impaired reverse cholesterol transport and rapidly changing status of sex hormones. (en)
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| Title
| - Menopausal transition enhances the atherogenic risk of smoking in middle aged women
- Menopausal transition enhances the atherogenic risk of smoking in middle aged women (en)
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| skos:prefLabel
| - Menopausal transition enhances the atherogenic risk of smoking in middle aged women
- Menopausal transition enhances the atherogenic risk of smoking in middle aged women (en)
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| skos:notation
| - RIV/00023001:_____/13:00057609!RIV14-MZ0-00023001
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| http://linked.open...avai/predkladatel
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00023001:_____/13:00057609
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - sex hormones; endothelial progenitor cell; reverse cholesterol transport; sublinical atherosclerosis; smoking; menopausal transition (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - International journal of cardiology
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Králová Lesná, Ivana
- Kovář, Jan
- Lánská, Věra
- Poledne, Rudolf
- Piťha, Jan
- Dvořáková, Hana
- Sekerková, Alena
- Bobak, Martin
- Adámková, Silvia
- Lejsková, Magdaléna
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| http://linked.open...ain/vavai/riv/wos
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| issn
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| number of pages
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| http://bibframe.org/vocab/doi
| - 10.1016/j.ijcard.2012.09.095
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