About: Time course of peritoneal function in automated and continuous peritoneal dialysis     Goto   Sponge   NotDistinct   Permalink

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  • BACKGROUND and OBJECTIVES: In automated peritoneal dialysis (APD), a patient's peritoneal membrane is more intensively exposed to fresh dialysate than it is in continuous ambulatory peritoneal dialysis (CAPD). Our aim was to study, in incident peritoneal dialysis (PD) patients, the influence of APD-compared with that of CAPD-on peritoneal transport over 4 years. Design, Setting, Participants, and Measurements: Patients were included if at least 2 annual standard permeability analyses (SPAs) performed with 3.86% glucose were available while the patient was using the same modality with which they had started PD (APD or CAPD). Patients were followed until their first modality switch. Differences in the pattern of SPA outcomes over time were tested using repeated-measures models adjusted for age, sex, comorbidity, primary kidney disease, and year of PD start. RESULTS: The 59 CAPD patients enrolled were older than the 47 APD patients enrolled (mean age: 58 +- 14 years vs 49 +- 14 years; p < 0.01), and they had started PD earlier (mean start year: 2000 vs 2002). Over time, no differences in solute (p > 0.19) or fluid transport (p > 0.13) were observed. Similarly, free water transport (p = 0.43) and small-pore transport (p = 0.31) were not different between the modalities. Over time, patients on APD showed a faster decline in effective lymphatic absorption rate (ELAR: p = 0.02) and in transcapillary ultrafiltration (TCUF: p = 0.07, adjusted p = 0.05). Further adjustment did not change the results. CONCLUSIONS: Compared with patients starting on CAPD, those starting on APD experienced a faster decline in ELAR and TCUF. Other transport parameters were not different over time between the groups.
  • BACKGROUND and OBJECTIVES: In automated peritoneal dialysis (APD), a patient's peritoneal membrane is more intensively exposed to fresh dialysate than it is in continuous ambulatory peritoneal dialysis (CAPD). Our aim was to study, in incident peritoneal dialysis (PD) patients, the influence of APD-compared with that of CAPD-on peritoneal transport over 4 years. Design, Setting, Participants, and Measurements: Patients were included if at least 2 annual standard permeability analyses (SPAs) performed with 3.86% glucose were available while the patient was using the same modality with which they had started PD (APD or CAPD). Patients were followed until their first modality switch. Differences in the pattern of SPA outcomes over time were tested using repeated-measures models adjusted for age, sex, comorbidity, primary kidney disease, and year of PD start. RESULTS: The 59 CAPD patients enrolled were older than the 47 APD patients enrolled (mean age: 58 +- 14 years vs 49 +- 14 years; p < 0.01), and they had started PD earlier (mean start year: 2000 vs 2002). Over time, no differences in solute (p > 0.19) or fluid transport (p > 0.13) were observed. Similarly, free water transport (p = 0.43) and small-pore transport (p = 0.31) were not different between the modalities. Over time, patients on APD showed a faster decline in effective lymphatic absorption rate (ELAR: p = 0.02) and in transcapillary ultrafiltration (TCUF: p = 0.07, adjusted p = 0.05). Further adjustment did not change the results. CONCLUSIONS: Compared with patients starting on CAPD, those starting on APD experienced a faster decline in ELAR and TCUF. Other transport parameters were not different over time between the groups. (en)
Title
  • Time course of peritoneal function in automated and continuous peritoneal dialysis
  • Time course of peritoneal function in automated and continuous peritoneal dialysis (en)
skos:prefLabel
  • Time course of peritoneal function in automated and continuous peritoneal dialysis
  • Time course of peritoneal function in automated and continuous peritoneal dialysis (en)
skos:notation
  • RIV/00023001:_____/12:00055998!RIV13-MZ0-00023001
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • N
http://linked.open...iv/cisloPeriodika
  • 6
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 174454
http://linked.open...ai/riv/idVysledku
  • RIV/00023001:_____/12:00055998
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • standard peritoneal permeability analysis; ultrafiltration; peritoneal transport; effective lymphatic absorption rate; continuous ambulatory peritoneal dialysis; Automated peritoneal dialysis (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CA - Kanada
http://linked.open...ontrolniKodProRIV
  • [04E3E7F62B45]
http://linked.open...i/riv/nazevZdroje
  • Peritoneal dialysis international
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 32
http://linked.open...iv/tvurceVysledku
  • Paříková, Alena
  • Boeschoten, Elisabeth W
  • Dekker, Friedo W
  • Krediet, Raymond T
  • Michels, Wieneke M
  • Struijk, Dirk G
  • Verduijn, Marion
http://linked.open...ain/vavai/riv/wos
  • 000311959500007
issn
  • 0896-8608
number of pages
http://bibframe.org/vocab/doi
  • 10.3747/pdi.2011.00166
is http://linked.open...avai/riv/vysledek of
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