| Attributes | Values |
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| rdf:type
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| rdfs:seeAlso
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| Description
| - Background/Aim: Triglycerides (TGs) are measured in studies evaluating changes in non-fasting lipid profiles after a fat tolerance test (FTT); however, the optimal timing for TG measurements after the oral fat load is unclear. The aim of this study was to evaluate how non-fasting TG levels vary after an oral FTT in healthy subjects. Methods: This meta-analysis included 113 studies with >5 participants of Caucasian race that were indexed in PubMed from its inception through March 2010, using the search term %22postprandial lipemia%22. We only included studies that provided mean values and standard deviation (SD) (or standard error of the mean) for TG measurements at baseline (=fasting) and for at least one other time-point. Exclusion criteria included uncommon sampling time-points after the FTT, baseline TGs >= 2.0 mmol/L (>= 177mg/dl), and a body mass index >= 30kg/m(2). Results: All studies combined, weighted mean +/- SD TG values in mmol/L were 1.25 +/- 0.32 fasting, 1.82 +/- 0.40 at 2 h, 2.31 +/- 0.62 at 4 h, 1.87 +/- 0.63 at 6 h, and 1.69 +/- 0.80 at 8 h. After stratifying studies based on fat quantity in the test meal (<40, >= 40-<50, >= 50-<60, <60-<70, >= 70-<80, >= 80-<90, >= 90-<100,>= 100-<110, >= 110-120, >= 120 g), the highest standardized mean difference in TG levels from fasting levels was found in those having an oral fat load of >= 70 g and <80 g, and at 4 h (difference=1.74 mmol/L; p<0.001). Conclusion: The 4 h time-point after an oral fat load during a FTT was the most representative measurement of TGs. The highest standardized mean difference of TGs was found after a meal containing 70-79g of fat. The relevance of these two key parameters determined in healthy subjects should be considered for further developments of an oral FFT for clinical purposes.
- Background/Aim: Triglycerides (TGs) are measured in studies evaluating changes in non-fasting lipid profiles after a fat tolerance test (FTT); however, the optimal timing for TG measurements after the oral fat load is unclear. The aim of this study was to evaluate how non-fasting TG levels vary after an oral FTT in healthy subjects. Methods: This meta-analysis included 113 studies with >5 participants of Caucasian race that were indexed in PubMed from its inception through March 2010, using the search term %22postprandial lipemia%22. We only included studies that provided mean values and standard deviation (SD) (or standard error of the mean) for TG measurements at baseline (=fasting) and for at least one other time-point. Exclusion criteria included uncommon sampling time-points after the FTT, baseline TGs >= 2.0 mmol/L (>= 177mg/dl), and a body mass index >= 30kg/m(2). Results: All studies combined, weighted mean +/- SD TG values in mmol/L were 1.25 +/- 0.32 fasting, 1.82 +/- 0.40 at 2 h, 2.31 +/- 0.62 at 4 h, 1.87 +/- 0.63 at 6 h, and 1.69 +/- 0.80 at 8 h. After stratifying studies based on fat quantity in the test meal (<40, >= 40-<50, >= 50-<60, <60-<70, >= 70-<80, >= 80-<90, >= 90-<100,>= 100-<110, >= 110-120, >= 120 g), the highest standardized mean difference in TG levels from fasting levels was found in those having an oral fat load of >= 70 g and <80 g, and at 4 h (difference=1.74 mmol/L; p<0.001). Conclusion: The 4 h time-point after an oral fat load during a FTT was the most representative measurement of TGs. The highest standardized mean difference of TGs was found after a meal containing 70-79g of fat. The relevance of these two key parameters determined in healthy subjects should be considered for further developments of an oral FFT for clinical purposes. (en)
|
| Title
| - Diagnostic value of postprandial triglyceride testing in healthy subjects: a meta-analysis
- Diagnostic value of postprandial triglyceride testing in healthy subjects: a meta-analysis (en)
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| skos:prefLabel
| - Diagnostic value of postprandial triglyceride testing in healthy subjects: a meta-analysis
- Diagnostic value of postprandial triglyceride testing in healthy subjects: a meta-analysis (en)
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| skos:notation
| - RIV/00023001:_____/11:00002511!RIV12-MZ0-00023001
|
| http://linked.open...avai/predkladatel
| |
| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/00023001:_____/11:00002511
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - Fat tolerance test; meta-analysis; postprandial lipaemia; standardized mean difference; triglycerides (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - AE - Stát Spojené arabské emiráty
|
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Current vascular pharmacology
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Anagnostopoulou, Katherine
- Bilianou, Helen
- Kovář, Jan
- Kolovou, Genovefa D
- Lairon, Dennis
- Mikhailidis, Dimitri P
- Nordestgaard, Borge G
- Ooi, Teik Chye
- Panotopoulos, George
- Perez-Martinez, Pablo
- Mihas, Constantinos
|
| http://linked.open...ain/vavai/riv/wos
| |
| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
| |
| http://bibframe.org/vocab/doi
| - 10.2174/157016111795495530
|
| is http://linked.open...avai/riv/vysledek
of | |
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