About: Number of serotonin positive cells and acute cellular rejection in the early period after small bowel transplantation in pigs

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Background. Small bowel transplantations (SBT) are being increasingly performed to treat patients with irreversible intestinal failure or short-bowel syndrome. Histologic evaluation of small bowel allograft biopsies is important for the diagnosis of acute cellular rejection (ACR). Serotonin (5 hydroxytriptamin) is a biogenous amine of which up to 95% is present in the enterochromaffin cells of the gastrointestinal tract. The aim of our study was to analyze rejection and number of serotonin positive cells in the intestinal graft biopsy samples early after SBT in pigs. Material and methods. 24 pigs were used and divided into 4 groups. Group A, autologous SBT (n = 3) as a control group; group B, allogeneic SBT with tacrolimus monotherapy (n = 7); group C, allogeneic SBT immunosuppressed with tacrolimus and sirolimus (n = 8); and group D, without immunosuppression (n = 6). Observation period was 30 days. Mucosal biopsies were obtained on days 0, 3, 5, 7, 10, 14, 20, 28 after transplantation. ACR was cla Background. Small bowel transplantations (SBT) are being increasingly performed to treat patients with irreversible intestinal failure or short-bowel syndrome. Histologic evaluation of small bowel allograft biopsies is important for the diagnosis of acute cellular rejection (ACR). Serotonin (5 hydroxytriptamin) is a biogenous amine of which up to 95% is present in the enterochromaffin cells of the gastrointestinal tract. The aim of our study was to analyze rejection and number of serotonin positive cells in the intestinal graft biopsy samples early after SBT in pigs. Material and methods. 24 pigs were used and divided into 4 groups. Group A, autologous SBT (n = 3) as a control group; group B, allogeneic SBT with tacrolimus monotherapy (n = 7); group C, allogeneic SBT immunosuppressed with tacrolimus and sirolimus (n = 8); and group D, without immunosuppression (n = 6). Observation period was 30 days. Mucosal biopsies were obtained on days 0, 3, 5, 7, 10, 14, 20, 28 after transplantation. ACR was cla (en)
Title	Number of serotonin positive cells and acute cellular rejection in the early period after small bowel transplantation in pigs Number of serotonin positive cells and acute cellular rejection in the early period after small bowel transplantation in pigs (en)
skos:prefLabel	Number of serotonin positive cells and acute cellular rejection in the early period after small bowel transplantation in pigs Number of serotonin positive cells and acute cellular rejection in the early period after small bowel transplantation in pigs (en)
skos:notation	RIV/00023001:_____/10:00002376!RIV11-MZ0-00023001
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NR8896)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Lodererová, Alena Honsová, Eva Oliverius, Martin Baláž, Peter
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	275575
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/10:00002376
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	serotonin; small bowel; transplantation (en)
http://linked.open.../riv/klicoveSlovo	serotonin transplantation small bowel
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[46AC4A86ABB1]
http://linked.open...i/riv/nazevZdroje	Biomedical papers
http://linked.open...in/vavai/riv/obor	FJ
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Experimental small bowel transplantation.
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	154
http://linked.open...iv/tvurceVysledku	Honsová, Eva Lodererová, Alena Oliverius, Martin Baláž, Peter
issn	1213-8118
number of pages	5 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Number of serotonin positive cells and acute cellular rejection in the early period after small bowel transplantation in pigs Number of serotonin positive cells and acute cellular rejection in the early period after small bowel transplantation in pigs Number of serotonin positive cells and acute cellular rejection in the early period after small bowel transplantation in pigs

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