About: Hepatocyte growth factor and antibodies to HLA and MICA antigens in heart transplant recipients

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Recent unconfirmed literature data suggest that elevated concentrations of the multifunctional cytokine hepatocyte growth factor (HGF) might be a marker of increased incidence of acute rejection after organ transplantation. The aim of this study was to test the hypothesis that HGF levels may correlate with the rejection and/or with the production of HLA and MHC Class I chain-related antigens A (MICA) specific antibodies. Sixty-three heart transplant recipients were included into the study. Hundred and eighty-five endomyocardial biopsies (EMB) obtained up to 6 months after transplantation were retrospectively analyzed for signs of cellular (CR) and antibody-mediated rejection (AMR). Pre- and post-transplant sera were tested for HGF concentrations and antibodies to HLA class I, class II and MICA antigens by xMap technology (Luminex). Pre-transplant HGF did not correlate with the incidence of CR or AMR. However, higher HGF concentrations correlated significantly with HLA antibody production before and Recent unconfirmed literature data suggest that elevated concentrations of the multifunctional cytokine hepatocyte growth factor (HGF) might be a marker of increased incidence of acute rejection after organ transplantation. The aim of this study was to test the hypothesis that HGF levels may correlate with the rejection and/or with the production of HLA and MHC Class I chain-related antigens A (MICA) specific antibodies. Sixty-three heart transplant recipients were included into the study. Hundred and eighty-five endomyocardial biopsies (EMB) obtained up to 6 months after transplantation were retrospectively analyzed for signs of cellular (CR) and antibody-mediated rejection (AMR). Pre- and post-transplant sera were tested for HGF concentrations and antibodies to HLA class I, class II and MICA antigens by xMap technology (Luminex). Pre-transplant HGF did not correlate with the incidence of CR or AMR. However, higher HGF concentrations correlated significantly with HLA antibody production before and (en)
Title	Hepatocyte growth factor and antibodies to HLA and MICA antigens in heart transplant recipients Hepatocyte growth factor and antibodies to HLA and MICA antigens in heart transplant recipients (en)
skos:prefLabel	Hepatocyte growth factor and antibodies to HLA and MICA antigens in heart transplant recipients Hepatocyte growth factor and antibodies to HLA and MICA antigens in heart transplant recipients (en)
skos:notation	RIV/00023001:_____/10:00002304!RIV11-MZ0-00023001
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NR9403), Z(MZ0IKEM2005)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Lodererová, Alena Honsová, Eva Netuka, Ivan Kolesár, Libor Stříž, Ilja Slavčev, Antonij Skibová, Jelena Málek, Ivan Šochman, Jan Pavlová, Yelena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	261399
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/10:00002304
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	acute rejection; heart transplantation; hepatocyte growth factor; HLA antibodies; MICA antibodies (en)
http://linked.open.../riv/klicoveSlovo	heart transplantation acute rejection HLA antibodies hepatocyte growth factor MICA antibodies
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[3A6E408B9C9C]
http://linked.open...i/riv/nazevZdroje	Tissue Antigens
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	10 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	DIAGNOSTICS OF HUMORAL REJECTION FOR ORGAN TRANSPLANTATION
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	76
http://linked.open...iv/tvurceVysledku	Honsová, Eva Lodererová, Alena Netuka, Ivan Skibová, Jelena Kolesár, Libor Málek, Ivan Slavčev, Antonij Stříž, Ilja Šochman, Jan Pavlová, Yelena
http://linked.open...ain/vavai/riv/wos	000282571400004
http://linked.open...n/vavai/riv/zamer	Výzkum kardiovaskulárních nemocí, diabetu a transplantace životně důležitých orgánů
issn	0001-2815
number of pages	7 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Hepatocyte growth factor and antibodies to HLA and MICA antigens in heart transplant recipients Hepatocyte growth factor and antibodies to HLA and MICA antigens in heart transplant recipients Hepatocyte growth factor and antibodies to HLA and MICA antigens in heart transplant recipients

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