About: Perfluorocarbon improves post-transplant survival and early kidney function following prolonged cold ischemia

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About: Perfluorocarbon improves post-transplant survival and early kidney function following prolonged cold ischemia Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Background: The two-layer organ preservation method (TLM) based on oxygenated perfluorocarbon overlaid with University of Wisconsin (UW) solution has been successfully used in clinical islet and experimental heart and intestine transplantation. We tested whether this technique would prevent tissue damage and improve kidney function in a model of syngeneic kidney transplantation with prolonged ischemia time. Methods: Kidneys were stored for 24 h either in UW solution (n = 16), with TLM (n = 16) or transplanted immediately (control group, n = 12). In half of the animals, survival was observed and in the other animals grafts were procured for semiquantitative histological scoring and TUNEL apoptosis assessment 24 h after transplantation. Results: One-month survival rates in the UW, TLM and control groups were 12.5, 62.5 and 100%, respectively (UW vs. TLM, p < 0.01). Median creatinine levels 24 h after transplantation were 381, 299 and 121 ?M, respectively (UW vs. TLM, p < 0.02). Histological scorin Background: The two-layer organ preservation method (TLM) based on oxygenated perfluorocarbon overlaid with University of Wisconsin (UW) solution has been successfully used in clinical islet and experimental heart and intestine transplantation. We tested whether this technique would prevent tissue damage and improve kidney function in a model of syngeneic kidney transplantation with prolonged ischemia time. Methods: Kidneys were stored for 24 h either in UW solution (n = 16), with TLM (n = 16) or transplanted immediately (control group, n = 12). In half of the animals, survival was observed and in the other animals grafts were procured for semiquantitative histological scoring and TUNEL apoptosis assessment 24 h after transplantation. Results: One-month survival rates in the UW, TLM and control groups were 12.5, 62.5 and 100%, respectively (UW vs. TLM, p < 0.01). Median creatinine levels 24 h after transplantation were 381, 299 and 121 ?M, respectively (UW vs. TLM, p < 0.02). Histological scorin (en)
Title	Perfluorocarbon improves post-transplant survival and early kidney function following prolonged cold ischemia Perfluorocarbon improves post-transplant survival and early kidney function following prolonged cold ischemia (en)
skos:prefLabel	Perfluorocarbon improves post-transplant survival and early kidney function following prolonged cold ischemia Perfluorocarbon improves post-transplant survival and early kidney function following prolonged cold ischemia (en)
skos:notation	RIV/00023001:_____/10:00002233!RIV11-MZ0-00023001
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NR9383)
http://linked.open...iv/cisloPeriodika	3-4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Saudek, František Zacharovová, Klára Marada, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	278470
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/10:00002233
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	schemia-reperfusion injury; perfluorocarbon; preservation methods; rat model; renal transplantation (en)
http://linked.open.../riv/klicoveSlovo	rat model renal transplantation perfluorocarbon preservation methods schemia-reperfusion injury
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[B59C5D824B7F]
http://linked.open...i/riv/nazevZdroje	European surgical research
http://linked.open...in/vavai/riv/obor	FJ
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Posttransplant function of ischemically impaired organs (pancreas, kidney, islets) preserved by oxygenated perfluorocarbon (PFC).
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	44
http://linked.open...iv/tvurceVysledku	Saudek, František Zacharovová, Klára Marada, Tomáš
http://linked.open...ain/vavai/riv/wos	000280518900006
issn	0014-312X
number of pages	9 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Perfluorocarbon improves post-transplant survival and early kidney function following prolonged cold ischemia Perfluorocarbon improves post-transplant survival and early kidney function following prolonged cold ischemia Perfluorocarbon improves post-transplant survival and early kidney function following prolonged cold ischemia

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