About: Bral1: Its role in diffusion barrier formation and conduction velocity in the CNS

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	At the nodes of Ranvier, excitable axon membranes are exposed directly to the extracellular fluid. Cations are accumulated and depleted in the local extracellular nodal region during action potential propagation, but the impact of the extranodal micromilieu on signal propagation still remains unclear. Brain-specific hyaluronan-binding link protein, Bral1, colocalizes and forms complexes with negatively charged extracellular matrix (ECM) proteins, such as versican V2 and brevican, at the nodes of Ranvier in the myelinated white matter. The link protein family, including Bral1, appears to be the linchpin of these hyaluronan-bound ECM complexes. Here we report that the hyaluronan-associated ECM no longer shows a nodal pattern and that CNS nerve conduction is markedly decreased in Bral1-deficient mice even though there were no differences between wild-type and mutant mice in the clustering or transition of ion channels at the nodes or in the tissue morphology around the nodes of Ranvier. However, changes At the nodes of Ranvier, excitable axon membranes are exposed directly to the extracellular fluid. Cations are accumulated and depleted in the local extracellular nodal region during action potential propagation, but the impact of the extranodal micromilieu on signal propagation still remains unclear. Brain-specific hyaluronan-binding link protein, Bral1, colocalizes and forms complexes with negatively charged extracellular matrix (ECM) proteins, such as versican V2 and brevican, at the nodes of Ranvier in the myelinated white matter. The link protein family, including Bral1, appears to be the linchpin of these hyaluronan-bound ECM complexes. Here we report that the hyaluronan-associated ECM no longer shows a nodal pattern and that CNS nerve conduction is markedly decreased in Bral1-deficient mice even though there were no differences between wild-type and mutant mice in the clustering or transition of ion channels at the nodes or in the tissue morphology around the nodes of Ranvier. However, changes (en)
Title	Bral1: Its role in diffusion barrier formation and conduction velocity in the CNS Bral1: Its role in diffusion barrier formation and conduction velocity in the CNS (en)
skos:prefLabel	Bral1: Its role in diffusion barrier formation and conduction velocity in the CNS Bral1: Its role in diffusion barrier formation and conduction velocity in the CNS (en)
skos:notation	RIV/00023001:_____/10:00002195!RIV11-MZ0-00023001
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0538), P(GA309/09/1597), P(NS9915), Z(AV0Z50390512)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Syková, Eva Voříšek, Ivan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	249195
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/10:00002195
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	magnetic resonance (en)
http://linked.open.../riv/klicoveSlovo	magnetic resonance
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[803CBE5B83CE]
http://linked.open...i/riv/nazevZdroje	Journal of Neuroscience
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	Role of the extracelullar matrix in the extracelullar space diffusion parameter changes during aging and the metabolic syndrome Center for Cell Therapy and Tissue Repair Properties of the extracellular space of the epileptic neocortex - significance for the pathogenesis and diagnosis of refractory epilepsy
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	30
http://linked.open...iv/tvurceVysledku	Syková, Eva Vargová, Lýdia Voříšek, Ivan Dmytrenko, Lesia Oohashi, Toshitaka Bekku, Yoko Fässler, Reinhard Goto, Yoshinobu Narasaki, Masahiro Ninomiya, Yoshifumi Ohtsuka, Aiji
http://linked.open...ain/vavai/riv/wos	000274930500032
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie
issn	0270-6474
number of pages	11 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Bral1: Its role in diffusion barrier formation and conduction velocity in the CNS Bral1: Its role in diffusion barrier formation and conduction velocity in the CNS

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