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  • The Immunosuppression in Pancreas Transplantation was historically based on the fact that the pancreas is an extremely immunogenic organ. Quadruple drug therapy with polyclonal or monoclonal antibodies induction was the mainstay therapy since the introduction of Cyclosporine A. In the modem era of Immunosuppression, Mycophenolate Mofetil replaced Azathioprine while Tacrolimus-another potent calcineurin inhibitor-had-and still has-a difficult challenge to replaced Cyclosporine A, due to its potential diabetogenic effect. Thanks to the first two EuroSPK studies which prospectively tried to answer several questions in that field. But. the future challenge will be in understanding the impact of innate immunity and ischemic reperfusion injuries on the long term graft function. Hopefully, new drugs will be available and tested to block unspecific deleterious reactions to attenuate the proinflammatory response. It will be the aim of the third Euro SPK Study.
  • The Immunosuppression in Pancreas Transplantation was historically based on the fact that the pancreas is an extremely immunogenic organ. Quadruple drug therapy with polyclonal or monoclonal antibodies induction was the mainstay therapy since the introduction of Cyclosporine A. In the modem era of Immunosuppression, Mycophenolate Mofetil replaced Azathioprine while Tacrolimus-another potent calcineurin inhibitor-had-and still has-a difficult challenge to replaced Cyclosporine A, due to its potential diabetogenic effect. Thanks to the first two EuroSPK studies which prospectively tried to answer several questions in that field. But. the future challenge will be in understanding the impact of innate immunity and ischemic reperfusion injuries on the long term graft function. Hopefully, new drugs will be available and tested to block unspecific deleterious reactions to attenuate the proinflammatory response. It will be the aim of the third Euro SPK Study. (en)
Title
  • Immunosuppression in pancreas transplantation: the Euro SPK trials and beyond
  • Immunosuppression in pancreas transplantation: the Euro SPK trials and beyond (en)
skos:prefLabel
  • Immunosuppression in pancreas transplantation: the Euro SPK trials and beyond
  • Immunosuppression in pancreas transplantation: the Euro SPK trials and beyond (en)
skos:notation
  • RIV/00023001:_____/08:00002234!RIV11-MZ0-00023001
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • N
http://linked.open...iv/cisloPeriodika
  • 6
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 371454
http://linked.open...ai/riv/idVysledku
  • RIV/00023001:_____/08:00002234
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • pancreas transplantation; immunosuppression (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • BE - Belgické království
http://linked.open...ontrolniKodProRIV
  • [252EB30BA0DC]
http://linked.open...i/riv/nazevZdroje
  • Acta chirurgica Belgica
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 108
http://linked.open...iv/tvurceVysledku
  • Adamec, Miloš
  • Steurer, W.
  • Saudek, František
  • Becker, T.
  • Bouček, Petr
  • Hoffmann, J.
  • Kožnarová, Radomíra
  • Malaise, J.
  • Bechstein, W. O.
  • Klempnauer, J.
  • Neuhaus, P.
  • Squifflet, J. P.
  • Arbogast, H.
  • Boas-Knoop, S.
  • Bonatti, H.
  • De Roover, A.
  • Dette, K.
  • Drognitz, O.
  • Hajt, T.
  • Havrdová, T.
  • Hopt, U.
  • Illner, WD.
  • Kahl, A.
  • Klar, E.
  • Königsrainer, A.
  • Land, W.
  • Lück, R.
  • Margreiter, R.
  • Mark, W.
  • Neipp, M.
  • Pascher, A.
  • Pisarski, P.
  • Pratschke, J.
  • Scharek, W.
  • Schlamp, A.
  • Seissler, J.
  • Thurow, C.
  • Viebahn, R.
  • Woeste, G.
  • Wunsch, A.
http://linked.open...ain/vavai/riv/wos
  • 000262975700008
issn
  • 0001-5458
number of pages
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