About: Renal activity of Akt kinase in experimental type 1 diabetes

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	V kůře ledvin byla měřena aktivita a exprese Akt a mTOR (kinase assay, western blottingem) u streptozotocinových-diabetických potkanů s rozdílnou úrovní diabetické kompenzace (glykémie 22.0+/-1.0, 13.4+/-1.5, 8.1+/-0.4 mmol/l, p<0.05 mezi skupinami), indukovanou podáváním různých dávek inzulinu (0, 4 and 12 IU/den), a u kontrolních potkanů s nebo bez podávání inzulinu. Glykemická kontrola a intenzita kompenzace diabetu inzulinem ukázyla, že reanální Akt a mTOR jsou důležité modulátory renální funkce při diabetu. (cs) Renal cortical activity and expression of Akt and mTOR (kinase assay, western blotting) were determined in streptozotocin-diabetic rats (D) with different levels of glycemic control (blood glucose 22.0+/-1.0, 13.4+/-1.5, 8.1+/-0.4 mmol/l, p<0.05 between the groups), achieved by varying insulin treatment (0, 4 and 12 IU/day), and in control rats with (C4) or without (C) chronic insulin administration. Renal Akt activity was reduced in D rats without insulin treatment and severe hyperglycemia (D-0, -62 %, p<0.01 vs. C), partially restored in moderately hyperglycemic rats (D-4, -30 %, p<0.05 vs. C), and normalized in D rats with intensive insulin and tight metabolic control (D-12). In conclusion, glycemic control and intensity of insulin treatment are important modulators of renal Akt and mTOR activity in diabetes. Renal cortical activity and expression of Akt and mTOR (kinase assay, western blotting) were determined in streptozotocin-diabetic rats (D) with different levels of glycemic control (blood glucose 22.0+/-1.0, 13.4+/-1.5, 8.1+/-0.4 mmol/l, p<0.05 between the groups), achieved by varying insulin treatment (0, 4 and 12 IU/day), and in control rats with (C4) or without (C) chronic insulin administration. Renal Akt activity was reduced in D rats without insulin treatment and severe hyperglycemia (D-0, -62 %, p<0.01 vs. C), partially restored in moderately hyperglycemic rats (D-4, -30 %, p<0.05 vs. C), and normalized in D rats with intensive insulin and tight metabolic control (D-12). In conclusion, glycemic control and intensity of insulin treatment are important modulators of renal Akt and mTOR activity in diabetes. (en)
Title	Renal activity of Akt kinase in experimental type 1 diabetes Renální aktivita Akt kinázy u experimentálního diabetu 1. typu (cs) Renal activity of Akt kinase in experimental type 1 diabetes (en)
skos:prefLabel	Renal activity of Akt kinase in experimental type 1 diabetes Renální aktivita Akt kinázy u experimentálního diabetu 1. typu (cs) Renal activity of Akt kinase in experimental type 1 diabetes (en)
skos:notation	RIV/00023001:_____/08:00001898!RIV09-MZ0-00023001
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MZ000023001)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Komers, Radko Kazdová, Ludmila Ždychová, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	392314
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/08:00001898
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	kidney; diabetic rats; glucose; mTOR; insulin (en)
http://linked.open.../riv/klicoveSlovo	glucose insulin mTOR kidney diabetic rats
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[7F86B5976F0D]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	57
http://linked.open...iv/tvurceVysledku	Komers, Radko Kazdová, Ludmila Ždychová, Jana Veselá, J.
http://linked.open...ain/vavai/riv/wos	000260893500007
http://linked.open...n/vavai/riv/zamer	Nové aspekty patofyziologie, prevence, diagnostiky a léčby nejzávažnějších onemocnění v české populaci
issn	0862-8408
number of pages	7 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Renal activity of Akt kinase in experimental type 1 diabetes Renal activity of Akt kinase in experimental type 1 diabetes Renal activity of Akt kinase in experimental type 1 diabetes Renal activity of Akt kinase in experimental type 1 diabetes

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