About: Variants within the ghrelin gene - association with HDL-cholesterol, but not with body mass index

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About: Variants within the ghrelin gene - association with HDL-cholesterol, but not with body mass index Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	ghrelin, hormon, stravovací návyky, potrava, energetická bilance, BMI, koncentrace lipidů (cs) Ghrelin is a hormone which influences eating habits, the amount of food ingested and the body's energy balance. We examined whether genetic variants in the ghrelin gene are associated with BMI, WHR and plasma lipid levels. We have evaluated the influence of ghrelin polymorphisms (Arg51>Gln, Leu72>Met and Gln90>Leu) on BMI, WHR, and plasma lipid levels in 1,191 males and 1,368 females representatively selected from the Czech population. Anthropometrical and biochemical parameters were analysed in two different years. In the entire population, we have detected 4.8% of carriers of the Gln51 allele, 14.2% carriers of the Met72 allele, and 10.9% of the Leu90 allele. Frequencies did not differ between males and females and alleles were not in linkage disequilibrium. BMI or WHR were not influenced by variants in the ghrelin gene. The ghrelin variant Leu72>Met was associated with elevated levels of plasma HDL-cholesterol. Compared to Leu/ Leu homozygotes, the Met carriers had lower HDL-choles Ghrelin is a hormone which influences eating habits, the amount of food ingested and the body's energy balance. We examined whether genetic variants in the ghrelin gene are associated with BMI, WHR and plasma lipid levels. We have evaluated the influence of ghrelin polymorphisms (Arg51>Gln, Leu72>Met and Gln90>Leu) on BMI, WHR, and plasma lipid levels in 1,191 males and 1,368 females representatively selected from the Czech population. Anthropometrical and biochemical parameters were analysed in two different years. In the entire population, we have detected 4.8% of carriers of the Gln51 allele, 14.2% carriers of the Met72 allele, and 10.9% of the Leu90 allele. Frequencies did not differ between males and females and alleles were not in linkage disequilibrium. BMI or WHR were not influenced by variants in the ghrelin gene. The ghrelin variant Leu72>Met was associated with elevated levels of plasma HDL-cholesterol. Compared to Leu/ Leu homozygotes, the Met carriers had lower HDL-choles (en)
Title	Variants within the ghrelin gene - association with HDL-cholesterol, but not with body mass index Varianty v genu pro ghrelin - souvislost s HDL-cholesterolem, ne však s indexem tělesné hmoty (cs) Variants within the ghrelin gene - association with HDL-cholesterol, but not with body mass index (en)
skos:prefLabel	Variants within the ghrelin gene - association with HDL-cholesterol, but not with body mass index Varianty v genu pro ghrelin - souvislost s HDL-cholesterolem, ne však s indexem tělesné hmoty (cs) Variants within the ghrelin gene - association with HDL-cholesterol, but not with body mass index (en)
skos:notation	RIV/00023001:_____/07:00001577!RIV08-MZ0-00023001
http://linked.open.../vavai/riv/strany	202-206
http://linked.open...avai/riv/aktivita	N
http://linked.open...avai/riv/aktivity	N
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Škodová, Zdenka Hubáček, Jaroslav Adámková, Věra Bohuslavová, Romana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	457537
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/07:00001577
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ghrelin; cholesterol (en)
http://linked.open.../riv/klicoveSlovo	ghrelin cholesterol
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[9F96FE13DC13]
http://linked.open...i/riv/nazevZdroje	Folia biologica (Praha)
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	53
http://linked.open...iv/tvurceVysledku	Adámková, Věra Hubáček, Jaroslav Škodová, Zdenka Bohuslavová, Romana
issn	0015-5500
number of pages	5 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Variants within the ghrelin gene - association with HDL-cholesterol, but not with body mass index Variants within the ghrelin gene - association with HDL-cholesterol, but not with body mass index Variants within the ghrelin gene - association with HDL-cholesterol, but not with body mass index

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