About: Cytokine gene polymorphisms in the Dutch population

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Vzorek holandské populace byl testován na zastoupení 22 různých polymorfismů genů pro 13 vybraných cytokinů v porovnání s českou a italskou populací. Ukázalo se, že holandská populace se ve frekvenci některých alel liší od italské, nikoliv od české populace. (cs) Numerous studies have shown that variations in the production and activity of cytokines influence the susceptibility and/or resistance to various infectious agents, autoimmune diseases, and cancer, as well as the predisposition to allograft rejection. Differences in the production of cytokines between individuals are often caused by single nucleotide polymorphisms (SNP) in the promoter or coding regions of cytokine genes. The cytokine polymorphisms of 107 unrelated Caucasian individuals originating from various parts of the Netherlands were studied and compared with the results of two European (Czech and Italian) populations. Twenty-two SNPs of 13 different cytokine genes were analysed. To test the Hardy-Weinberg equilibrium, allele frequencies were estimated by direct gene counting. Evaluation of the allele frequencies of the Dutch, Italian and Czech populations showed that five SNPs were significantly different between the Dutch and the Italians, while these SNPs did not vary between the Dutch and t Numerous studies have shown that variations in the production and activity of cytokines influence the susceptibility and/or resistance to various infectious agents, autoimmune diseases, and cancer, as well as the predisposition to allograft rejection. Differences in the production of cytokines between individuals are often caused by single nucleotide polymorphisms (SNP) in the promoter or coding regions of cytokine genes. The cytokine polymorphisms of 107 unrelated Caucasian individuals originating from various parts of the Netherlands were studied and compared with the results of two European (Czech and Italian) populations. Twenty-two SNPs of 13 different cytokine genes were analysed. To test the Hardy-Weinberg equilibrium, allele frequencies were estimated by direct gene counting. Evaluation of the allele frequencies of the Dutch, Italian and Czech populations showed that five SNPs were significantly different between the Dutch and the Italians, while these SNPs did not vary between the Dutch and t (en)
Title	Cytokine gene polymorphisms in the Dutch population Cytokine gene polymorphisms in the Dutch population (en) Genové polymorfismy cytokinů v holandské populaci (cs)
skos:prefLabel	Cytokine gene polymorphisms in the Dutch population Cytokine gene polymorphisms in the Dutch population (en) Genové polymorfismy cytokinů v holandské populaci (cs)
skos:notation	RIV/00023001:_____/07:00000817!RIV08-MZ0-00023001
http://linked.open.../vavai/riv/strany	87-90
http://linked.open...avai/riv/aktivita	N P
http://linked.open...avai/riv/aktivity	N, P(NR7859), P(NR8276), P(NR8981)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Kolesár, Libor Stříž, Ilja Slavčev, Antonij
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	415542
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/07:00000817
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	genotypes. HLA (en)
http://linked.open.../riv/klicoveSlovo	genotypes. HLA
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[2271D5A91ADF]
http://linked.open...i/riv/nazevZdroje	International journal of immunogenetics
http://linked.open...in/vavai/riv/obor	FE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Antibodies to HLA antigens and their relevance for the develpoment of chronic rejection after kidney transplantation The role of renal epithelium and gene polymorphisms of proinflammatory cytokines in allograft rejection NK receptors´ gene polymorphisms in the Czech population
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	34
http://linked.open...iv/tvurceVysledku	Kolesár, Libor Slavčev, Antonij Stříž, Ilja Škorpil, N. Lardy, N.
issn	1744-3121
number of pages	4 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Cytokine gene polymorphisms in the Dutch population Cytokine gene polymorphisms in the Dutch population Cytokine gene polymorphisms in the Dutch population

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