| Attributes | Values |
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| rdf:type
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| Description
| - lidský leukocytární antigen (HLA), protilátky (cs)
- Background. Human leukocyte antigen (HLA)-C is expressed on nucleated cells and platelets in lower levels than HLA-A,B, and its antigens are in linkage disequilibrium with HLA-B antigens. Therefore, HLA-C antibody detection is difficult. The authors questioned whether HLA-C could serve as a target in clinical kidney transplantation using a newly developed assay. Methods. Flow cytometry was performed with sera from patients (n=34) awaiting a kidney retransplant using nine cell lines expressing a single HLA-C antigen (single-antigen lines [SAL]). Results. The SAL were validated with HLA-C-specific alloantisera and human monoclonal antibodies against HLA-A, -B, and -C. The results were in agreement with the specificities previously reported. Exceptions, because of new HLA-C specificities used here, could be explained by epitope sharing between the antigens. With respect to patient sera, 15 of the 34 patients tested (44%) showed serum reactivity toward one or more HLA-C SAL. Conclusions. In contr
- Background. Human leukocyte antigen (HLA)-C is expressed on nucleated cells and platelets in lower levels than HLA-A,B, and its antigens are in linkage disequilibrium with HLA-B antigens. Therefore, HLA-C antibody detection is difficult. The authors questioned whether HLA-C could serve as a target in clinical kidney transplantation using a newly developed assay. Methods. Flow cytometry was performed with sera from patients (n=34) awaiting a kidney retransplant using nine cell lines expressing a single HLA-C antigen (single-antigen lines [SAL]). Results. The SAL were validated with HLA-C-specific alloantisera and human monoclonal antibodies against HLA-A, -B, and -C. The results were in agreement with the specificities previously reported. Exceptions, because of new HLA-C specificities used here, could be explained by epitope sharing between the antigens. With respect to patient sera, 15 of the 34 patients tested (44%) showed serum reactivity toward one or more HLA-C SAL. Conclusions. In contr (en)
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| Title
| - Single-antigen-expressing cell lines are excellent tools for detecting human leukocyte. Antigen-C-reactive antibodies in kidney transplant recipients
- Single-antigen-expressing cell lines are excellent tools for detecting human leukocyte. Antigen-C-reactive antibodies in kidney transplant recipients (en)
- Linie buněk exprimujících jediný antigen představují vynikající nástroj pro zjišťování lidských leukocytů. Protilátky reagující na HLA-C u příjemců ledvinového štěpu (cs)
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| skos:prefLabel
| - Single-antigen-expressing cell lines are excellent tools for detecting human leukocyte. Antigen-C-reactive antibodies in kidney transplant recipients
- Single-antigen-expressing cell lines are excellent tools for detecting human leukocyte. Antigen-C-reactive antibodies in kidney transplant recipients (en)
- Linie buněk exprimujících jediný antigen představují vynikající nástroj pro zjišťování lidských leukocytů. Protilátky reagující na HLA-C u příjemců ledvinového štěpu (cs)
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| skos:notation
| - RIV/00023001:_____/05:00001288!RIV08-MZ0-00023001
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00023001:_____/05:00001288
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - nephrology; transplantology (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Böhmová, Radka
- Zoet, Y. M.
- Claas, F. H. J.
- Doxiadis, I. I. N.
- Eijsink, CH.
- Franke, M. E. I.
- Kardol, M. J.
- Mulder, A.
- Witvliet, M. D.
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| issn
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| number of pages
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| is http://linked.open...avai/riv/vysledek
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