About: Laboratory of Structure and Dynamics of Biomolecules

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=VS96095
Description	The subject of the proposal is to create Laboratory of Biomolecular Structure and Dynamics. An efficient scientific program is proposed, which will ensure that two recent large investment activities (the supercomputer project and the NMR instrument) willefficiently be used. The project is a combination of NMR spectroscopy, X-ray crystallography and computer modeling. The scientific goals include both methodoly development and its applications on biologically interesting molecules. The systems studied will include oligonucleotides, peptides, carbohydrates, nucleotide-sugars, and proteins. The strategical direction for high technology will be biodegradation in the environment. (en) Předmětem projektu je vytvoření laboratoře struktury a dynamiky biomolekul. Základní metodika obnáší: NMR spektroskopii, rentgenovou difrakci, počítačovou chemii a molekulové modelování. Předmětem studia jsou jak malé a střední biomolekuly (oligonukleotidy, cukry), tak biopolymery (proteiny).
Title	Laboratory of Structure and Dynamics of Biomolecules (en) Laboratoř struktury a dynamiky biomolekul
skos:notation	VS96095
http://linked.open...avai/cep/aktivita	Strengthening of research at the universities
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/VS96095/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/VS96095/celkoveNaklady
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	597341
http://linked.open...ai/cep/hlavniObor	CC - Organická chemie
http://linked.open...hodnoceniProjektu	U - Uspěl podle zadání, tj. byly splněny cíle a jeho předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory
http://linked.open.../cep/klicovaSlova	biomolecular structure and dynamics, structural biology, computer modeling, NMR spectroscopy, X-ray (en)
http://linked.open...ep/partnetrHlavni	Přírodovědecká fakulta
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open.../pocetVysledkuRIV	41 (xsd:int)
http://linked.open...enychVysledkuVRIV	41 (xsd:int)
http://linked.open...iciPoslednihoRoku	2001
http://linked.open...atUdajeProjZameru	2001
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open.../cep/vedlejsiObor	CD - Makromolekulární chemie
http://linked.open...jektu+dodavatelem	Laboratoř struktury a dynamiky biomolekul, která je kompozicí čtyř výzk. skupin v oblastech NMR spektroskopie biomolekul, počítač. modelování a simulací biomolekul, protein. inženýrství dehalogenáz a rentg. krystalografie biomolekul zahrnujíce proteiny. (cs)
http://linked.open...tniCyklusProjektu	ZBBBKU
http://linked.open.../cep/klicoveSlovo	NMR spectroscopy computer modeling structural biology biomolecular structure and dynamics
is http://linked.open...vavai/riv/projekt of	Heteronuclear coupling konstants-a tool for the stereochemical molecular studies Sanguinarine Pseudobase: Re-examination of NMR Assignments Using Gradient-Enhanced Spectroscopy Differences in Conformational Behavior of ATA and TAT Sequences in Single Strand DNA Trimer Differentiation Between Isomeric Phenylglycidyl Ether Adducts of 2 Differentiation Between Isomeric Phenylglycidyl Ether Adducts of 2´-Deoxyguanosine and 2´-Deoxyguanosine-5´-monophosphate Using Liquid Chromatography/Electrospray Tandem Mass Spectrometry Pyridoxine as a Substrate for Screening Synthetic Potential of Glycosidases Regioselective preparation of N7- and N9-alkyl derivatives of N6-[(Dimethylamino)methylene]adenine bearing active methylene group and their further derivatization leading to alpha-branched acyclic nucleotide analogues Quantum Chemical Calculations of the Chemical Shifts of Benzo[c]phenanthridine Alkaloids Regioselective preparation of N 7 - and N 9 -alkyl derivatives of N 6 -[(dimethylamino)methylene]adenine bearing an active methylene group and their further derivatization leading to .alfa.-branched acyclic nucleoside analogues. Hydrogen Bonding Effects on the N-15 and H-1 Shielding Tensors in Nucleic Acid Base Pairs Reaction mechanism and stereochemistry of gamma-hexachlorocyclohexane dehydrochlorinase LinA Purification, crystallization and preliminary X-ray analysis of a maize cytokinin glucoside specific beta-glucosidase. Structural Studies of Isoquinoline Alkaloids by NMR Spectroscopy Structural studies of benzo[c]phenanthridine alkaloid free bases by NMR spectroscopy Unrestrained Molecular Dynamics Simulations of d(AT5]2 Duplex in Aqueous Solution: Hydration and Sodium Ions Binding in the Minor Groove. 15N NMR Studies of Nitrogen Heterocycles: Examples on Tautomerism and Regioisomerism 1H-, 13C-, 15N-NMR and Quantum-Chemical Study of the Quaternary Benzo[c]phenanthridine Alkaloids and Their Bases 15N NMR studies on tautomerism and regioisomerism of nitrogen heterocycles 15N NMR Spectroscopy of Purine Derivatives Structure and Transformations of the Alkaloid Sanguilutine Structural Studies of Chelirubine and Chelilutine Free Bases 15N NMR studium isochinolinových alkaloidů Application of 15N NMR to the Study of Heterocycles Structural Studies Using Gradient Inverse 15N NMR Spectroscopy An A-type Double Helix of DNA Having B-type Puckering of the Deoxyribose Rings A Method for Direct Determination of Helical Parameters in Nucleic Acids Using Residual Dipolar Couplings 15N NMR study of isoquinoline alkaloids 1H and 13C NMR Study of Quaternary Benzo[c]phenanthridine Alkaloids 1H, 13C, 15N NMR Study of Benzo[c]phenanthridine and Other Isoquinoline Alkaloids 15N NMR Study of Natural and Synthetic Nitrogen Heterocycles Docking-Based Development of Purine-like Inhibitors of Cyclin-Dependent Kinase 2 Norsanguinarine-Quantum Chemical Calculations of the Chemical Shifts Single-coordinate-driving method for molecular docking: Application to modeling of guest inclusion in cyclodextrin Determination of a Symmetrical Dimer Structure in Benzo[c]phenanthridine Alkaloids by Pulsed-Field-Gradient HMBC Determination of 15N chemical shifts and remote connectivities in selected alkaloids by gradient-enhanced inverse-detected NMR experiments Gradient - enhanced HSQC experiments for phase-sensitive detection of multiple bond interactions. Gradient-enhanced inverse-detected NMR techniques for determination of 1H-15N coupling constants in 2,2-dimethylpenta-3,4-dienal derivatives (+)-Catechin: Benzoyl protection of OH groups and NMR study of Products Conformational Study of C2 Symmetrical Benzo[c]phenantridine Alkaloid Derivatives (-)-Armepavine: Gradient-enhanced 2D-NMR study and X-ray crystal structure determination Molecular dynamics of DNA quadruplex molecules containing inosine, 6-thioguanine and 6-thiopurine
is http://linked.open...vavai/cep/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/VS96095/1996/ico%3A00216224 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/VS96095/1997/ico%3A00216224 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/VS96095/1998/ico%3A00216224 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/VS96095/1999/orjk%3A14310 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/VS96095/2000/orjk%3A14310 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/VS96095/2001/orjk%3A14310

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