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  • The project will follow two branches improving the following fields of interests: A) BIOTECHNOLOGY – i.e. research on pharmaceutical forms of photosensitizers for the photodynamic treatment of cancer diseases resulting in their optimalization. B) LASER TECHNOLOGY – i.e. coordinated development interconnected with the development of photosensitizers and new light sources for the photodynamic therapy of tumours. AIMS A) We intend to develop an industrial manufacturing of new formulations of photosenzitizers for photodynamic therapy (PDT) of tumors based on hyhobic derivatives of phtalocyanines, for which a Czech patent was awarded and PCT patent applications were submitted (authors Ježek, Nekvasil, Poučková.). We will adapt the patented procedure with the regulations of Good Manufacture Practice (GMP) according to the European Union rules in the case of microfludization procedures. We will solve prevention of lipid oxidation during the procedure and test liposomal stability in gel formulations we (en)
  • Rozvineme nové fotosenzitizátory pro fotodynamickou terapii tumorů i její instrumentální část, - lampy a laserové zařízení. Vypracujeme ve správné výrobní praxi a dle předpisů SÚKL postup přípravy preparátu s uděleným patentem, včetně jejich zdokonalení.
Title
  • Technology for photodynamic therapy of tumors (en)
  • Technologie pro fotodynamickou terapii nádorových onemocnění
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  • OE09026
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  • Photodynamic therapy of tumors pharmacy: liposomal gel drug formulations terapeutic lasers for medicine lamps for photodynamic therapy of tumors (en)
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  • Drug formulation of hydrophobic aluminum phthalocyanine for photodynamic therapy of tumors was improved in aGMP regime including nanoparticle formulation and was tested on athymic nude mice on xenotransplanted human tumors and a compatible 2.5 W laser generator was constructed with fiber optics. (en)
  • Pro fotodynamickou terapii zhoubných nádorů byla zdokonalena soustava lékové formy nesulfonovaného ftalocyaninu hydroxyhlinitého včetně formy nanočásticové v režimu přípravy správné výrobní praxe a otestována na lidských tumorech implantovaným athymickým nu nu myším a kompatibilně byl zkonstruován funkční vzorek 2.5 W polovodičového laserového generátoru s vláknovým světlovodem. (cs)
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