About: Transplantation of the embryonic cerebellar tissue and stem cells into the cerebellum of Lurcher mutant and normal mice     Goto   Sponge   NotDistinct   Permalink

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Description
  • The aim of the project is to investigate long-term survival of embryonic cerebellar tissue in the form of a solid graft or cell suspension and suspension of embryonic carcinoma stem cells-derived neuroprogenitors grafted into the cerebellum of adult Lurcher mutant and normal wild type mice and to examine the effect of transplantation on motor function of Lurcher mice. Lurcher mutant mice will be used as a natural model of hereditary olivocerebellar degeneration. Wild type mice will represent healthy controls. 2 and 6 months after surgery the mice will undergo a rotarod testing, gait examination and brain histological examination of presence and state of the graft. We will compare survival and possible functional effect of individual types of the grafts and their survival in Lurcher mice with affected cerebellum and in wild type mice with healthy cerebellum. Long-term survival and its functional manifestation 6 months after transplantation will be compared with those 2 months after the transplantation (en)
  • Zkoumat dlouhodobé přežívání embryonální tkáně mozečku a neuroprogenitorů odvozených z nádorových kmenových buněk transplantovaných do mozečku mutantních myší Lurcher a normálních myší typu wild, zkoumat vliv transplantace na pohybové funkce myší Lrucher
Title
  • Transplantation of the embryonic cerebellar tissue and stem cells into the cerebellum of Lurcher mutant and normal mice (en)
  • Transplantace embryonální tkáně mozečku a embryonálních nádorových kmenových buněk do mozečku normálních a mutantních myší Lurcher
skos:notation
  • OC10038
http://linked.open...avai/cep/aktivita
http://linked.open...kovaStatniPodpora
http://linked.open...ep/celkoveNaklady
http://linked.open...datumDodatniDoRIV
http://linked.open...i/cep/druhSouteze
http://linked.open...ep/duvernostUdaju
http://linked.open.../cep/fazeProjektu
http://linked.open...ai/cep/hlavniObor
http://linked.open...hodnoceniProjektu
http://linked.open...vai/cep/kategorie
http://linked.open.../cep/klicovaSlova
  • cerebellar ataxia; Lurchermutant mice; neurotransplantation; olivocerebellar degeneration (en)
http://linked.open...ep/partnetrHlavni
http://linked.open...inujicichPrijemcu
http://linked.open...cep/pocetPrijemcu
http://linked.open...ocetSpoluPrijemcu
http://linked.open.../pocetVysledkuRIV
http://linked.open...enychVysledkuVRIV
http://linked.open...lneniVMinulemRoce
http://linked.open.../prideleniPodpory
http://linked.open...iciPoslednihoRoku
http://linked.open...atUdajeProjZameru
http://linked.open.../vavai/cep/soutez
http://linked.open...usZobrazovaneFaze
http://linked.open...ai/cep/typPojektu
http://linked.open...ep/ukonceniReseni
http://linked.open.../cep/vedlejsiObor
http://linked.open...ep/zahajeniReseni
http://linked.open...jektu+dodavatelem
  • It was found that the neuroprogenitor graft survived in lower percentage in Lurcher than in wild type mice and than the embryonic grafts. The transplantation did not have positive effect on motor functions of Lurchers. The time after the transplantation did not influence the fate of the graft. The outputs were 1 article in a journal with an IF, 1 article without an IF and in 9 abstracts. (en)
  • Bylo zjištěno nižší přežívání neuroprogonitorového transplantátu u myší Lurcher než u myší typu wild a než přežívání embryonálních transplantátů. Transplantace neměla pozitivní účinek na motorické funkce myší Lurcher. Doba po transplantaci neměla významný vliv na osud transplantátu. Výstupem je 1 článek v časopise s IF, 1 článek v recenzovaném časopise bez IF a 9 sjezdových abstraktů. (cs)
http://linked.open...tniCyklusProjektu
http://linked.open.../cep/klicoveSlovo
  • cerebellar ataxia
  • Lurchermutant mice
  • neurotransplantation
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