About: Modulation of TNF-alpha and IL-1 activity as the treatment option during endotoxin induced organ injury.     Goto   Sponge   NotDistinct   Permalink

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Description
  • The present project is aimed at physiologically based evaluation of pharmacokinetics and pharmacodynamics of compounds with special attention paid to transport systems in the liver and kidney. These transport systems are highly altered during endotoxemia, a common clinical problem, produced by lipopolysaccharides released from gramnegative bacteria. Because the whole cascade of events is initiated by proinflammatory stimuli, appropriate suppression of inflammation may reduce organ impairment. Therefore, the present extension of previous COST project aimed at finishing of started works to allow matching of in vivo anti-inflammatory potential of corticosteroids and IL-1-antagonists with the function and expression of basic excretory pathways in the liver and kidney during endotoxemia. Validated rat in vivo pathophysiological model of toxic liver and renal injury will be used to evaluate bile acid kinetics, expression of transport and regulatory molecules in respective tissue together with histological (en)
  • Cílem předkládaného projektu je zhodnocení potenciálu kortikosteroidů a blokátorů IL-1 receptorů v léčbě endotoxinem navozeného postižení jater, plic a ledvin za použití validovaného in vivo potkaního modelu a molekulárně-biologických metod.
Title
  • Modulation of TNF-alpha and IL-1 activity as the treatment option during endotoxin induced organ injury. (en)
  • Modulace aktivity TNF-alfa a IL-1 jako potenciální léčebná strategie endotoxinem navozeného orgánového poškození
skos:notation
  • OC09072
http://linked.open...avai/cep/aktivita
http://linked.open...kovaStatniPodpora
http://linked.open...ep/celkoveNaklady
http://linked.open...datumDodatniDoRIV
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http://linked.open...ep/duvernostUdaju
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http://linked.open.../cep/klicovaSlova
  • endotoxemia; glucocorticoids; anakinra (en)
http://linked.open...ep/partnetrHlavni
http://linked.open...inujicichPrijemcu
http://linked.open...cep/pocetPrijemcu
http://linked.open...ocetSpoluPrijemcu
http://linked.open.../pocetVysledkuRIV
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http://linked.open...ep/ukonceniReseni
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http://linked.open...ep/zahajeniReseni
http://linked.open...jektu+dodavatelem
  • Předkládaný projekt přináší informace o pozivním vlivu dvou protizánětlivých léčiv, dexametazonu a ankinry (antagonicty IL-1 receptorů) na endotocinem navozené poškození transportu léčiv v játrech a ledvinách. (cs)
  • The present project brings date about positive influence of two antiinflammatory drugs, dexamethasone and anakinra (IL-1 receptor antagonist) on the ecdotoxin-induced alteration of drug transport in the liver and kidneys. (en)
http://linked.open...tniCyklusProjektu
http://linked.open.../cep/klicoveSlovo
  • endotoxemia
  • glucocorticoids
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