About: Gene polymorphisms and intrarenal expression of genes in Focal segmental glomerulosclerosis and their relation to progression of the disease     Goto   Sponge   NotDistinct   Permalink

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  • I: To observe a correlation among an intrarenal expression of genes for MCP-1, RANTES, TGFbeta1, HGF, BMP and VEGF, an infiltration of renal tissue by leukocytes, an ammount of proteinuria and the progression of FSGS. II: To investigate if the carriers of a gene polymorphism causing high production of the inflammation cytokines have higher risk of significant proteinuria and progression of FSGS. (en)
  • Anotace I: Sledovat korelaci mezi intrarenální expresí genů pro MCP-1, RANTES, TGFbeta1, HGF, BMP a VEGF, infiltrací ledvinné tkáně leukocyty, výší proteinurie a progrese Fokálně segmentální glomerulosklerózy. Anotace II: Zjistit, zda nositelé vlohy pro vysokou produkci prozánětlivých cytokinů mají vyšší riziko vzniku klinicky závažné proteinurie a progrese Fokálně segmentální glomerulosklerózy
Title
  • Gene polymorphisms and intrarenal expression of genes in Focal segmental glomerulosclerosis and their relation to progression of the disease (en)
  • Polymorfismy a intrarenální exprese prozánětlivých genů u Fokálně segmentální glomerulosklerózy a jejich vztah k průběhu onemocnění
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  • FSGS; polymorphisms; expression of genes; proteinuria; cytokines; fibrosis; biopsy (en)
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  • In 50 pts with FSGS and IgA nefropathy we analyzed 90 ren. gene expressions and found specif. immune gene profiles in FSGS and other pts group. Analysis of C/A polymorphism of VEGF showed increased prevalence of CC genotype in FSGS (en)
  • U 50 pts s FSGS a IgA nefropath. bylo vyhodnoceno 90 genů exprimovaných v ledvinách a prokázáno, že FSGS a další skupiny se liší v profilech imunitní gen. exprese. Analýza C/A polymorf. VEGF prokázala zvýšenou prev. CC genotyp u FSGS (cs)
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  • cytokines
  • polymorphisms
  • expression of genes
  • fibrosis
  • proteinuria
  • FSGS
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