| Attributes | Values |
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| rdf:type
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| rdfs:seeAlso
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| Description
| - Osteoporosis is a complex polygenic disease. The objective of the project are recent candidate genes (calcium-sensing receptor, osteoprotegerin and LDL receptor-related protein 5), their sequence variations and bone metabolism in postmenopausal women. Pharmacogenetics - a relationship between calciotropic hormone receptor polymorphisms (VDR - vitamin D, CALCR- calcitonin and ESR1- estrogen receptors) and bone response to 1,25(OH)2D3, estrogen and calcitonin treatment. (en)
- Osteoporóza je komplexní polygenní choroba. Předmětem projektu jsou nové kandidátní geny (calcium-sensing receptor, osteoprotegerin a s LDL receptorem asociovaný protein),jejich sekvenční variability a kostní metabolizmus u postmenopauzálních žen. Farmakogenetika - vztah mezi polymorfizmy v genech pro receptory hlavních kalciotropních látek (VDR-vitamin D, CALCR-kalcitonin a ESR1-estrogeny) a odpovědí kosti na léčbu (podávání 1,25(OH)2D3, kalcitoninu a estrogenní substituce).
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| Title
| - Genetic aspects of osteoporosis - new candidate genes and their sequence variations in relation to bone metabolism and pharmacological response in postmenopausal women (en)
- Genetické aspekty osteoporózy - nové kandidátní geny a jejich sekvenční variability ve vztahu ke kostnímu metabolizmu a farmakologické odpovědi u postmenopauzálních žen
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...hodnoceniProjektu
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
| - osteoporosis; bone density; polymorphisms (SNP); CASR gene; OPG gene; LRP5 gene; pharmacogenetics; menopause (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...okUkonceniPodpory
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| http://linked.open...okZahajeniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open...jektu+dodavatelem
| - Polymorfizmy v kandidátních genech pro osteoporózu (CASR,LRP,VDR,OPG) byly významně asociovány s řadou kostních, metabolických a endokrinních parametrů u žen v menopauze.Studie ukazuje možný pleiotropní vliv sekvenčních variabilit. (cs)
- Polymorphisms in osteoporosis-related candidate genes(CASR,LRP5,VDR,OPG) were associated with a range of bone, metabolic and endocrine parametres in women at menopause. The study suggests a possible pleiotropic effect of genetic sequence variations. (en)
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| http://linked.open...tniCyklusProjektu
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| http://linked.open.../cep/klicoveSlovo
| - osteoporosis
- pharmacogenetics
- CASR gene
- LRP5 gene
- OPG gene
- bone density
- polymorphisms (SNP)
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| is http://linked.open...vavai/riv/projekt
of | |
| is http://linked.open...vavai/cep/projekt
of | |
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