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| Description
| - Recent studies show an increase in the occurence of testicular tumors, in developmental defects of male reproductive organs, and a decrease in the quality of sperm - these are symptomps of one underlying entity - the dysgenesis syndrom. The difference in localization of sperm, cytoskeletal and heat shock proteins in the sperm between healthy and subfertile men will be tested by specific antibodies. Different proteins in seminal plasma will be evaluated and characterized. Selected endocrine disruptors will used to induce pathological states of reproductive organs and spermatozoa in experimental mouse system. Different parameters of damage (of sperm proteins, cytoskeleton, heat shock proteins) will be tested. The project offers new methods and tools (monoclonal antibodies) for the evaluation of male infertility and for the detection of negative factors which can induce infertility. (en)
- V poslední době dochází k nárustu nádorů testes, různých abnormalit a snížení kvality spermatu. Tyto faktory shrnuje %22Testicular dysgenesis syndrom%22 (TDS). Snižování kvality životního prostředí působí na TDS. Detekce/exprese podobných proteinů bude testována u spermií a v semenné plasmě mužů s normálním a patologickým spermiogramem. Budou porovnány výsledky %22experimentální patologie%22 s patologií u neplodných mužů. Vybrané endokrinní disruptory navodí patologické stavy u zvířat v experimentálním systému. Různé parametry poškození reprodukčních orgánů a spermií budou hodnoceny (proteiny spermie, cytoskelet, %22heat shock%22 proteiny). Projekt poskytne nové, objektivní a citlivé metody a nástroje (monoklonální protilátky) k hodnocení mužské neplodnosti a upozorní na možné negativní faktory, které mohou neplodnost indukovat.
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| Title
| - Male infertility, sperm and seminal plasma status, damage biomarkers. (en)
- Neplodnost mužů, stav spermií a semenné plasmy, biomarkery poškození.
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...hodnoceniProjektu
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
| - Human environment;Men infertility;Endocrine disruptors;Intra-acrosomal proteins;Seminal plasma;Cytoskeleton;Heat shock proteins;Diagnostic kit (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...okUkonceniPodpory
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| http://linked.open...okZahajeniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open.../cep/vedlejsiObor
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| http://linked.open...jektu+dodavatelem
| - Acros. proteins of hum.sperm are important for fertilization also in ICSI.Antibodies against these proteins can be used for detection of pathology,selection of useful method of IVF and detection of spermatogenesis.Endocrine disruptors have negat. effect. (en)
- Akrosom. proteiny lidských spermií (vazebné,cytoskeletální) jsou rozhodující pro oplození v ICSI.Protilátky proti těmto proteinům detekují patologii,výběr vhodné metody IVF a průkaz spermatogenese.Endokrinní disruptory mají negativní vliv na reprodukci. (cs)
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| http://linked.open...tniCyklusProjektu
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| http://linked.open.../cep/klicoveSlovo
| - Endocrine disruptors
- Seminal plasma
- Cytoskeleton
- Heat shock proteins
- Human environment
- Intra-acrosomal proteins
- Men infertility
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| is http://linked.open...vavai/riv/projekt
of | - Detekce spermatid v ejakulátu neplodných mužů pomocí monoklonálních protilátek proti proteinům spermie
- Detection of spermatids in ejaculates of infertile males with monoclonal antibodies against intra-acrosomal sperm proteins
- Detection of tubulin epitopes in human sperm ejaculates with normal and pathological spermiograms
- Identification and isolation of boar sperm specific antigens with potential role in sperm-egg interaction
- Mannan-binding proteins from boar seminal plasma
- Characterization of human seminal plasma proteins homologous to boar AQN spermadhesins
- Monoclonal antibodies against sperm intra-acrosomal antigens as marker for male infertility diagnostics as estimation of spermatogenesis
- Characterization of peptide proteinase inhibitors isolated from boar seminal plasma.
- Isolation, characterization and binding properties of boar epididymal fluid proteins
- Interactions of boar sperm surface proteins in the fertilization process
- Interactions of boar sperm surface proteins with porcine oviductal epithelium
- Interakce povrchových proteinů spermií v reprodukčním procesu
- Immunofluorescent localization and characterization of human sperm coating protein recognized by Hs-9 monoclonal antibody
- Lectin-like interactions of boar sperm surface proteins with glycoconjugates of porcine oviduct
- Study of fish sperm proteins using monoclonal antibodies
- Sperm AKAPs in the triangular part of the equatorial subdomain of boar sperm during capacitation, hyperactivation, and induced acrosomal reaction
- Sperm AKAPs - their regulation and associated protein during capacitation, activation and induced acrosomal reaction
- Acrosome integrity as a sensitive marker of sperm quality.
- Estimation of the post-meiotic state of spermatogenesis in man by immunofluorescence with monoclonal antibodies against intra-acrosomal sperm proteins.
- Aggregated forms of bull seminal plasma proteins and their heparin-binding activity
- Acrosomal integrity of mammalian spermatozoa evaluated by monoclonal antibodies to intra-acrosomal proteins and role of these proteins in sperm-egg binding
- Saccharide-mediated interactions of boar sperm surface proteins with components of the porcine oviduct
- Evaluation of reproductive potential after intracytoplasmic sperm injection of varied human semen tested by antiacrosomal antibodies
- The in vitro biological activity of Lepidium meyenii extracts
- Characterization of human seminal plasma proteins homologous to boar spermadhesin AQN
- Dynamic and role of cytosekeletal proteins in mammalian sperm cells.
- Sperm proteins detectedf with Hs-14 monoclonal antibody.
- Serine proteinases and their inhibitors in fertilization
- Mutual interactions of boar seminal proteins studied by immunological and chromatographic methods
- Mutual interactions of boar seminal plasma proteins studied by immunological and chromatographic methods.
- Multigenerational study - effect of the selected compounds on the mouse fertility.
- Role of sperm surface proteins in gamete binding.
- Regulation and localization of sperm akaps during capacitation, activation, induced acrosomal reaction and binding to the oocyte.
- Regulation and localization of sperm akaps during capacitation, activation, induced acrosomal reaction and binding to oocyte.
- Characterization of peptide proteinase inhibitors isolated from boar seminal plasma.
- Boar epididymal fluid proteins: their isolation and characterization.
- Characterization of peptide proteinase inhibitors isolated from boar seminal plasma.
- Human seminal plasma proteins immunobiochemically related to boar AQN 1 spermadhesin: their partial biochemical characterization.
- The implantation rate of 31,5 per year 2002 - comprehensive azoosúermia solution by iscare IVF a.s.
- ISOLATION AND CHARACTERIZATION OF MANNAN-BINDING PROTEINS FROM BOAR SEMINAL PLASMA.
- Proteinase inhibitors in aggregated forms of boar seminal plasma proteins
- Study of sperm proteins in modelspecies of chondrostean and teleostean fish.
- Biochemical characterization of proteins from human seminal plasma immunobiochemically related to boar spermadhesin AQN 1
- Application of antibodies against sperm acrosomal proteins as probes to detection of human sperm pathology and prediction of spermatogenesis
- Boar seminal plasma proteins and their binding properties
- Boar epididymal fluid proteins
- Characterization of human seminal plasma proteins homologous to boar spermadhesin AQN 1
- Body and oragan weight, sperm acrosomal status and reproduction ofter genistern and diethylatilbestrol treatment of CD 1 mice in a multigenerational study.
- Boar seminal plasma proteins and their binding prperties. A review.
- The role of boar sperm surface proteins in saccharide-mediated events in the female reproductive tract
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| is http://linked.open...vavai/cep/projekt
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