About: Genetic factors influencing the development of celiac disease in Type 1 diabetic children.     Goto   Sponge   NotDistinct   Permalink

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  • Proposed study will investigate the contribution of susceptible genotypes (HLA-DQ, CTLA4 polymorphism, cytokine genes polymorphism) for the high frequency of celiac disease in children with Type 1 diabetes. (en)
  • Pomocí analýzy rizikových genů (HLA II. třídy, polymorfismy CTLA4 a cytokinových genů) kvantifikujeme vliv jednotlivých polymorfismů na vznik celiakie u dětí s DM1. Studie umožní stratifikovat diabetické děti podle rizika vzniku celiakie.
Title
  • Genetic factors influencing the development of celiac disease in Type 1 diabetic children. (en)
  • Genetické faktory ovlivňující vznik celiakie u dětí s diabetes mellitus 1. typu.
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  • NB7413
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  • Type 1 diabetes;Celiac disease;genetic susceptibility;HLA polymorphism;CTLA-4;Cytokine genes;children;multicenter study (en)
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  • Riziko celiakie (CD) je u dětí s diabet. melit. 1.typu (T1D) modifikováno genet.-přítomností HLA-DQB1*02-DQA1*05,polymorfismů TNF-308A a IL1-alfa-889T. Asymptom. CD nemá efekt na kontrolu T1D a riziko AITD,neg.ovlivňuje hmotnost a BMI u dětí s T1D. (cs)
  • The risk of celiac disease in children with T1D is signif.modified by HLA-DQB1*02-DQA1*05,TNF-308A a IL1-alfa-889Tpolymorphisms.Silent CD has no obvious effect on metabolic control and the risk of AITD,neg.influences weight gain in children with T1D. (en)
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http://linked.open.../cep/klicoveSlovo
  • children
  • genetic susceptibility
  • Type 1 diabetes
  • Celiac disease
  • CTLA-4
  • Cytokine genes
  • HLA polymorphism
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