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  • Traumatic spinal cord injury leads in the local spinal cord segment to massive loss of neurons and glial cells that are needed for the continued survival and normal function of remaining neuronal elements. Loss of local neuronal networks at the injury site as well as the interruption of axonal pathways carrying sensory information to the brain and descending motor control pathways to the spinal cord leads to permanent functional deficits. Transplantation of cells leads in rhodents and primates to improvement in neurological functions. The cells subjected to the transplantation experiments include stem cells derived from embryonic stem cells, adult neural stem cells or bone marrow-derived stem cells. The therapeutic effects of transplantation are probably caused by several mechanisms including (i) replacement of lost cells, (ii) production of neurotrophic factors that promote proliferation of endogenous cells and (iii) remyelination of existing axons in the lesion proximity. Whilst the transplanted s (en)
  • Cílem předkládaného projektu je charakterizace změn, které provázejí míšní poranění, na úrovni proteinů a identifikace znaků, které umožní sledovat průběh terapie míšního poškození pomocí transplantace kmenových buněk/prekurzorových buněk.
Title
  • Proteomic characterization of spinal cord injury and determination of cells suitable for cell grafting (en)
  • Proteomová charakterizace míšního poškození a selekce buněk vhodných pro transplantační terapii
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  • ME10044
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  • spinal cord injury; cell grafting; embryonic stem cells; neural stem cells; neuronal precursors; proteomics; antibody microarrays; secreted proteins (en)
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  • V projektu jsme se soustředili na proteomické profilování míšní tkáně po traumatickém poškození na modelu potkanů. Dále jsme ověřovali změny typické pro neurální diferenciaci na úrovni buněčných i sekretovaných proteinů/peptidů. Nedílnou součástí je presentace výsledků na mezinárodních a národních konferencích se zaměřením na proteomiku, kmenové buňky a buněčnou terapii. (cs)
  • The research was focused in proteomic profiling of spinal cord after traumatic injury using rat model. Furthermore, changes typical for neural differentiation at the level of cellular and secreted proteins/peptides vere verified. Importantly, the results are presented in international and national conferences in the fields of proteomics, stem cells and cell therapy. (en)
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  • spinal cord injury
  • embryonic stem cells
  • proteomics
  • antibody microarrays
  • cell grafting
  • neural stem cells
  • neuronal precursors
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