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  • Photoactivatable compounds (also called caged compounds) are systems which, upon photoactivation, either (1) irreversibly release a species possessing desirable physical, chemical, or biological qualities, while the groups that are responsible for the photoprocess are referred to as photoremovable; or (2) reversibly induce physical or chemical changes in a system; in such cases, they are called photochemical switches and the process is usually photochromic (photochromism is a reversible chemical transformation, induced in one or both directions by the absorption of light, between two forms having different absorption spectra and other photophysical properties). Photoactivatable compounds are of a great interest in connection with biochemical and biological applications (e.g., photoregulations of proteins and enzyme activity, neurotransmitters, ATP, and Ca2+ delivery, or photoactivatable fluorophores), organic synthesis (e.g., photoremovable protecting groups; solid-phase synthesis; microarray fabrica (en)
  • 1. Syntéza nových fotoaktivovatelných/fotoodštěpitelných systémů pro biologii 2. Kinetické studie na připravených derivátech 3. Biologické studie na připravených derivátech
Title
  • New photoactivatable systems for biological studies (en)
  • Vývoj nových fotoaktivovatelných systémů pro biologické studie
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  • ME09021
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  • Photochemistry (en)
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  • Předmětem projektu ME 09021 byl návrh, studium a vývoj fotoaktivovatelných systémů pro chemická a biochemická využití ve spolupráci s laboratoří Prof. Richarda S. Givense z University of Kansas, USA. Projektu se zúčastnilo 9 Ph.D. studentů z Masarykovy univerzity. Výsledky výzkumu byly publikovány v renomovaných odborných časopisech. (cs)
  • The subject of the ME 09021 project was a design, study and development of the photoactivatable compounds for chemical and biochemical application in collaboration with Professor Richard S. Givens from University of Kansas, USA. 9 Ph.D. students participated on the project. The research results were published in the prestigious scientific journals. (en)
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