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| Description
| - Status epilepticus (SE) is a clinical emergency with a prevalence of 0.1%, with approximately 50% of the cases occurring in children younger than 2 years of age. Retrospective studies indicate that up to 80% of patients with drug-refractory temporal lobe epilepsy in adulthood had childhood SE or prolonged febrile seizures. Up to 60% of patients exhibit neurological sequelae as a consequence of SE. Studies on experimental animals demonstrate that pattern and severity of SE-induced functional and morphological damage are highly age-dependent. Extension of neuronal loss and cognitive or behavioural impairment increase with age at SE. In contrast, age affects pattern and severity of recurrent seizures rather than incidence of epilepsy in surviving individuals. Thus, we hypothesize that neuronal loss is not only factor responsible for functional impairment, but there are other age-related morphological changes involved in both acute and long-term consequences of SE. Among them white matter injury can repr (en)
- Cílem projektu je zjistit, jestli status epilepticus v nezralém mozku vyvolává poškození bílé hmoty, jakou roli hraje v tomto poškození zánětlivá reakce, a jak je rozsah a charakter poškození (včetně vzniku epilepsie) ovlivněn tělesnou teplotou během SE.
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| Title
| - White matter injury as a consequence of status epilepticus in immature rats. (en)
- Poškození bílé hmoty mozkové v důsledku status epilepticus v průběhu postnatálního vývoje laboratorního potkana.
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...hodnoceniProjektu
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
| - Status epilepticus - inflamation - white matter - immature rats (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open...ep/ukonceniReseni
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| http://linked.open.../cep/vedlejsiObor
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| http://linked.open...ep/zahajeniReseni
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| http://linked.open...jektu+dodavatelem
| - Naše výsledky dokazují, že časný status epilepticus vede k progresivní atrofii temporálních struktur, neurodegeneraci a ke vzniku epilepsie. Rozsah hipokampální atrofie koreluje s poškozením kognitivních funkcí, nikoli však s tíží epilepsie. Tíže neuropatologických I funkčních změn je zvýšena působením hypertermie v průběhu SE. Tato data naznačují, že horečka představuje důležitý rizikový faktor. (cs)
- Results of the project demonstrate that early status epilepticus leads to progressive atrophy of temporal lobe structures, neurodegeneration and epilepsy development. The extent of hippocampal atrophy correlates with cognitive impairment but not with severity of epilepsy. Hyperthermia during SE aggravates severity of morphologic and functional consequences suggesting important role of fever. (en)
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| http://linked.open...tniCyklusProjektu
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| is http://linked.open...vavai/riv/projekt
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| is http://linked.open...vavai/cep/projekt
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